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    Klk1b24 kallikrein 1-related peptidase b24 [ Mus musculus (house mouse) ]

    Gene ID: 16617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klk1b24provided by MGI
    Official Full Name
    kallikrein 1-related peptidase b24provided by MGI
    Primary source
    MGI:MGI:892021
    See related
    Ensembl:ENSMUSG00000063713 AllianceGenome:MGI:892021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klk24; mGk-24
    Summary
    This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in colon adult (RPKM 79.3), kidney adult (RPKM 55.5) and 5 other tissues See more
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    Genomic context

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    See Klk1b24 in Genome Data Viewer
    Location:
    7 B3; 7 28.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43837658..43841879)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44188234..44192455)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b22 Neighboring gene kallikrein 1-related peptidase b16 Neighboring gene kallikrein 1-related peptidase b23, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18787 Neighboring gene kallikrein 1-related peptidase b3 Neighboring gene kallikrein 1-related pepidase b4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24. Matsui H, et al. Zoolog Sci, 2005 Oct. PMID 16286722
    2. Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells. Matsui H, et al. Int J Biochem Cell Biol, 2005 Nov. PMID 15985384
    3. Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity. Matsui H, et al. Eur J Biochem, 2000 Dec. PMID 11082197
    4. Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. Isbel L, et al. PLoS Genet, 2015 Dec. PMID 26624618, Free PMC Article
    5. Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene. van Leeuwen BH, et al. J Biol Chem, 1986 Apr 25. PMID 3007510

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein 1-related peptidase b24
    Names
    glandular kallikrein K24
    tissue kallikrein 24
    NP_034773.1
    XP_006540737.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010643.2 → NP_034773.1  kallikrein 1-related peptidase b24 preproprotein

      See identical proteins and their annotated locations for NP_034773.1

      Status: REVIEWED

      Source sequence(s)
      AB039277, BC146019
      Consensus CDS
      CCDS21198.1
      UniProtKB/Swiss-Prot
      A6H6V7, Q61754, Q61755, Q9JM69
      Related
      ENSMUSP00000073392.7, ENSMUST00000073713.8
      Conserved Domains (2) summary
      smart00020
      Location:24 → 255
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25 → 258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43837658..43841879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540674.3 → XP_006540737.1  kallikrein 1-related peptidase b24 isoform X1

      UniProtKB/TrEMBL
      A0A1R3UCH3
      Conserved Domains (1) summary
      smart00020
      Location:24 → 252
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61754.3 GenPept UniProtKB/Swiss-Prot:Q61754

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