Zik1 zinc finger protein interacting with K protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zik1provided by MGI
Official Full Name: zinc finger protein interacting with K protein 1provided by MGI
Primary source: MGI:MGI:108070
See related: Ensembl:ENSMUSG00000030393 AllianceGenome:MGI:108070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; peripheral nervous system; and retina. Orthologous to human ZIK1 (zinc finger protein interacting with K protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 9.0), CNS E14 (RPKM 8.3) and 11 other tissues See more
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Genomic context

Location:: 7 A1; 7 6.47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (10221151..10229308, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (10487224..10495381, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Title: Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Zik1 (e-PCR), detects polymorphism
- UniSTS:515991

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein interacting with ribonucleoprotein K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009577.3 → NP_033603.2 zinc finger protein interacting with ribonucleoprotein K

See identical proteins and their annotated locations for NP_033603.2

Status: VALIDATED

Source sequence(s)

AC159008, BC050942, BY026558

Consensus CDS

CCDS20792.1

UniProtKB/Swiss-Prot

P70405, Q80YP6

Related

ENSMUSP00000032551.8, ENSMUST00000032551.8

Conserved Domains (4) summary

COG5048
Location:112 → 425

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:357 → 377

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 52

KRAB; KRAB box

pfam13465
Location:342 → 366

zf-H2C2_2; Zinc-finger double domain