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    Kcns1 K+ voltage-gated channel, subfamily S, 1 [ Mus musculus (house mouse) ]

    Gene ID: 16538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcns1provided by MGI
    Official Full Name
    K+ voltage-gated channel, subfamily S, 1provided by MGI
    Primary source
    MGI:MGI:1197019
    See related
    Ensembl:ENSMUSG00000040164 AllianceGenome:MGI:1197019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv9.1
    Summary
    Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transmembrane transport. Located in perinuclear region of cytoplasm and plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 4.4), limb E14.5 (RPKM 3.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcns1 in Genome Data Viewer
    Location:
    2 H3; 2 84.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164005539..164013865, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164163619..164171113, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene STARR-positive B cell enhancer ABC_E6014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163910112-163910326 Neighboring gene serine/threonine kinase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:163954265-163954566 Neighboring gene RIKEN cDNA A730032A03 gene Neighboring gene predicted gene, 53202 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. Tsantoulas C, et al. Pain, 2018 Aug. PMID 29697531, Free PMC Article
    2. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895
    3. Ion channel expression in the developing enteric nervous system. Hirst CS, et al. PLoS One, 2015. PMID 25798587, Free PMC Article
    4. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    delayed-rectifier potassium channel regulatory subunit KCNS1; potassium voltage-gated channel subfamily S member 1
    Names
    delayed-rectifier K(+) channel alpha subunit 1
    delayed-rectifier potassium channel subunit Kv9.1
    potassium voltage-gated channel modifier subfamily S member 1
    voltage-gated potassium channel subunit Kv9.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008435.2 → NP_032461.2  delayed-rectifier potassium channel regulatory subunit KCNS1

      See identical proteins and their annotated locations for NP_032461.2

      Status: VALIDATED

      Source sequence(s)
      AF008573, AK158889, AL591512, AW047812, BY127291
      Consensus CDS
      CCDS17022.1
      UniProtKB/Swiss-Prot
      A2A5M1, O35173
      UniProtKB/TrEMBL
      Q3TY49
      Related
      ENSMUSP00000038901.4, ENSMUST00000045196.4
      Conserved Domains (2) summary
      cl38908
      Location:21 → 126
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:188 → 439
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164005539..164013865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158792.1 → XP_036014685.1  potassium voltage-gated channel subfamily S member 1 isoform X1

      UniProtKB/Swiss-Prot
      A2A5M1, O35173
      UniProtKB/TrEMBL
      Q3TY49
      Conserved Domains (2) summary
      cl38908
      Location:21 → 126
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:188 → 439
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35173.2 GenPept UniProtKB/Swiss-Prot:O35173

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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