Cdh22 cadherin 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh22provided by MGI
Official Full Name: cadherin 22provided by MGI
Primary source: MGI:MGI:1341843
See related: Ensembl:ENSMUSG00000053166 AllianceGenome:MGI:1341843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; heart; limb; limb bud; and retina. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.43 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164953421..165076892, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (165111501..165234924, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells.
Title: AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Janus kinase 2 protein (JAK2) and beta-catenin were found to interact with cadherin-22 (Cdh22) and involved in CDH22 signaling in female germ line stem cells (FGSCs).
Title: Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin.
Results describe the expression of Cdh22 in developing mouse brain and compare it to expression of related family members.
Title: Analysis of Cdh22 expression and function in the developing mouse brain.
spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei
Title: Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

Cdh22 (e-PCR), detects polymorphism
- UniSTS:547856

UniSTS:224287 (e-PCR)
- UniSTS:224287

M-09659 (e-PCR)
- UniSTS:186255

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cadherin-22

Names: PB-cadherin; pituitary and brain cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174988.3 → NP_778153.2 cadherin-22 precursor

See identical proteins and their annotated locations for NP_778153.2

Status: VALIDATED

Source sequence(s)

AK140248, AL591411, BC112407

Consensus CDS

CCDS17073.1

UniProtKB/Swiss-Prot

I7HIP9, Q9WTP5

Related

ENSMUSP00000066864.7, ENSMUST00000065438.13

Conserved Domains (2) summary

cd11304
Location:398 → 492

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:645 → 804

Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164953421..165076892 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157158.1 → XP_036013051.1 cadherin-22 isoform X2

Conserved Domains (2) summary

cd11304
Location:276 → 370

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:523 → 682

Cadherin_C; Cadherin cytoplasmic region
XM_006498536.5 → XP_006498599.1 cadherin-22 isoform X4

Conserved Domains (3) summary

cd11304
Location:95 → 193

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:22 → 90

CA; Cadherin repeats

pfam01049
Location:241 → 400

Cadherin_C; Cadherin cytoplasmic region
XM_036157156.1 → XP_036013049.1 cadherin-22 isoform X1

UniProtKB/Swiss-Prot

I7HIP9, Q9WTP5

Conserved Domains (2) summary

cd11304
Location:398 → 492

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:645 → 804

Cadherin_C; Cadherin cytoplasmic region
XM_006498534.4 → XP_006498597.1 cadherin-22 isoform X2

Conserved Domains (2) summary

cd11304
Location:276 → 370

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:523 → 682

Cadherin_C; Cadherin cytoplasmic region
XM_030246473.2 → XP_030102333.1 cadherin-22 isoform X3

Conserved Domains (1) summary

cd11304
Location:398 → 492

Cadherin_repeat; Cadherin tandem repeat domain