Tm4sf4 transmembrane 4 superfamily member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tm4sf4provided by MGI
Official Full Name: transmembrane 4 superfamily member 4provided by MGI
Primary source: MGI:MGI:2385173
See related: Ensembl:ENSMUSG00000027801 AllianceGenome:MGI:2385173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iltmp
Summary: Predicted to be active in membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human TM4SF4 (transmembrane 4 L six family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 65.5), liver E18 (RPKM 54.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 27.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (57332831..57349098)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (57425410..57441677)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Tm4sf4 is localized to the ductal epithelium and Ngn3(+) islet progenitor cells, and that pancreatic tm4sf4 expression and regulation by Nkx2.2 is conserved during development.
Title: The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane 4 L6 family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.