Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh2provided by MGI
Official Full Name: myosin, heavy polypeptide 2, skeletal muscle, adultprovided by MGI
Primary source: MGI:MGI:1339710
See related: Ensembl:ENSMUSG00000033196 AllianceGenome:MGI:1339710
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MHC2A; Myh2a; Myhs-f; Myhsf1; MyHC-2a; Myhs-f1; MyHC-IIa
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to muscle activity. Located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myopathy 6 and inclusion body myositis. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 15.2), kidney adult (RPKM 2.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.59 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67061853..67088343)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67171027..67197517)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
Title: Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
Title: Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
myosin IIa is essential for B cell development, proliferation, and antibody responses.
Title: Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation.
nonmuscle myosin 2A replacement with myosin 2C1 permits gastrulation but not placenta vascular development in mice
Title: Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice.
Inhibition of myosin IIA decreases annexin 1 nuclear translocation in oxygen-glucose deprivation.
Title: Following OGD/R, annexin 1 nuclear translocation and subsequent induction of apoptosis in neurons are assisted by myosin IIA in a TRPM7 kinase-dependent manner.
Myh2 expression was significantly higher in ESCs-mechanical group than that in the same group of MSCs.
Title: Comparing the effect of uniaxial cyclic mechanical stimulation and chemical factors on myogenin and Myh2 expression in mouse embryonic and bone marrow derived mesenchymal stem cells.
Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
Title: Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
Myosin IIa has a role in upregulating early osteogenesis
Title: Substrate curvature sensing through Myosin IIa upregulates early osteogenesis.
Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice
Title: Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids.
Increase of CYP1A1-mRNA was due to nonmuscle myosin II inhibition.
Title: Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh2 (e-PCR), detects polymorphism
- UniSTS:143956

Myh2 (e-PCR), detects polymorphism
- UniSTS:143957

Myh2 (e-PCR), detects polymorphism
- UniSTS:265578

D11Mit5 (e-PCR), detects polymorphism
- UniSTS:126596

RH65760 (e-PCR)
- UniSTS:19394

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin-mediated cell contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to muscle activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle myosin complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-2

Names: myosin heavy chain 2; myosin heavy chain 2A; myosin heavy chain IIa; myosin heavy chain, skeletal muscle, adult 2; skeletal muscle myosin heavy chain II-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039545.2 → NP_001034634.2 myosin-2

See identical proteins and their annotated locations for NP_001034634.2

Status: VALIDATED

Source sequence(s)

AL596129

Consensus CDS

CCDS24854.2

UniProtKB/Swiss-Prot

G3UW82

UniProtKB/TrEMBL

B2RWX0

Related

ENSMUSP00000129544.2, ENSMUST00000170159.8

Conserved Domains (7) summary

cl22853
Location:100 → 773

Motor_domain; Myosin and Kinesin motor domain

pfam00063
Location:88 → 773

Myosin_head; Myosin head (motor domain)

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 73

Myosin_N; Myosin N-terminal SH3-like domain

cl00459
Location:1302 → 1414

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl19219
Location:1673 → 1770

DUF342; Protein of unknown function (DUF342)

cl23720
Location:968 → 1101

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

67061853..67088343

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144961.1: Suppressed sequence

Description

NM_144961.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.