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    Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult [ Mus musculus (house mouse) ]

    Gene ID: 17879, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myh1provided by MGI
    Official Full Name
    myosin, heavy polypeptide 1, skeletal muscle, adultprovided by MGI
    Primary source
    MGI:MGI:1339711
    See related
    Ensembl:ENSMUSG00000056328 AllianceGenome:MGI:1339711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IId; MdMs; IId/x; Myhs-f; Myhsf2; MHC2X/D; Myhs-f2; MHC-2X/D; MYHC-IIX; MyHC-IId/x; MyHC-IIx/d; A530084A17Rik
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 25.2), lung adult (RPKM 11.6) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myh1 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67090922..67115401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67200102..67224577)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29795 Neighboring gene STARR-seq mESC enhancer starr_29796 Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 2, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117705

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-1
    Names
    myHC-2x
    myosin heavy chain 1
    myosin heavy chain 2X
    myosin heavy chain, skeletal muscle, adult 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030679.2NP_109604.1  myosin-1

      See identical proteins and their annotated locations for NP_109604.1

      Status: VALIDATED

      Source sequence(s)
      AK041122, BC108329
      Consensus CDS
      CCDS24855.1
      UniProtKB/Swiss-Prot
      Q32P18, Q5SX40
      UniProtKB/TrEMBL
      B2RWX0
      Related
      ENSMUSP00000117569.2, ENSMUST00000124516.8
      Conserved Domains (3) summary
      cd14910
      Location:100773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67090922..67115401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314318.3XP_017169807.1  myosin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q32P18, Q5SX40
      UniProtKB/TrEMBL
      B2RWX0
      Related
      ENSMUSP00000018637.9, ENSMUST00000018637.15
      Conserved Domains (3) summary
      cd14910
      Location:100773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain