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    Lsm12 LSM12 homolog [ Mus musculus (house mouse) ]

    Gene ID: 268490, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lsm12provided by MGI
    Official Full Name
    LSM12 homologprovided by MGI
    Primary source
    MGI:MGI:1919592
    See related
    Ensembl:ENSMUSG00000020922 AllianceGenome:MGI:1919592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110059P07; 1110032E16Rik; 2600001B17Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cortical plate. Orthologous to human LSM12 (LSM12 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 18.6), CNS E11.5 (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsm12 in Genome Data Viewer
    Location:
    11 D; 11 65.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102053323..102077089, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102162497..102186268, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11586 Neighboring gene N-acetylglutamate synthase Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102017679-102017862 Neighboring gene transmembrane protein 101 Neighboring gene STARR-positive B cell enhancer ABC_E10715 Neighboring gene glucose 6 phosphatase, catalytic, 3 Neighboring gene histone deacetylase 5 Neighboring gene STARR-positive B cell enhancer ABC_E378 Neighboring gene microRNA 8101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    2. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    3. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
    4. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein LSM12
    Names
    protein LSM12 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172947.3 → NP_766535.1  protein LSM12

      See identical proteins and their annotated locations for NP_766535.1

      Status: PROVISIONAL

      Source sequence(s)
      AL954730, BX323852
      Consensus CDS
      CCDS25490.1
      UniProtKB/Swiss-Prot
      A2AWS3, Q9D0R8
      Related
      ENSMUSP00000021297.6, ENSMUST00000021297.6
      Conserved Domains (2) summary
      cd01735
      Location:7 → 67
      LSm12_N; Like-Sm protein 12, N-terminal domain
      smart00995
      Location:78 → 165
      AD; Anticodon-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102053323..102077089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533414.5 → XP_006533477.1  protein LSM12 isoform X1

      See identical proteins and their annotated locations for XP_006533477.1

      UniProtKB/Swiss-Prot
      A2AWS3, Q9D0R8
      Conserved Domains (2) summary
      cd01735
      Location:7 → 67
      LSm12_N; Like-Sm protein 12, N-terminal domain
      smart00995
      Location:78 → 165
      AD; Anticodon-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0R8.1 GenPept UniProtKB/Swiss-Prot:Q9D0R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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