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    Dnah17 dynein, axonemal, heavy chain 17 [ Mus musculus (house mouse) ]

    Gene ID: 69926, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnah17provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 17provided by MGI
    Primary source
    MGI:MGI:1917176
    See related
    Ensembl:ENSMUSG00000033987 AllianceGenome:MGI:1917176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1178; Dnahc17; Dnahcl1; mKIAA3028; 2810003K23Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to be located in sperm flagellum. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium and axoneme. Used to study spermatogenic failure 39. Human ortholog(s) of this gene implicated in spermatogenic failure 39. Orthologous to human DNAH17 (dynein axonemal heavy chain 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 14.0), thymus adult (RPKM 1.2) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Dnah17 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    83
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117912549..118021684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118021723..118130719, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31288 Neighboring gene STARR-positive B cell enhancer ABC_E7103 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene STARR-seq mESC enhancer starr_31291 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene microRNA 6933 Neighboring gene STARR-positive B cell enhancer ABC_E7104 Neighboring gene STARR-seq mESC enhancer starr_31293 Neighboring gene STARR-seq mESC enhancer starr_31294 Neighboring gene STARR-seq mESC enhancer starr_31295 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117947366-117947549 Neighboring gene STARR-positive B cell enhancer ABC_E1438 Neighboring gene STARR-positive B cell enhancer ABC_E9849 Neighboring gene predicted gene 11738 Neighboring gene STARR-seq mESC enhancer starr_31297 Neighboring gene predicted gene, 38514 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118017777-118018078 Neighboring gene cytohesin 1 Neighboring gene STARR-positive B cell enhancer ABC_E7106 Neighboring gene STARR-positive B cell enhancer ABC_E9850 Neighboring gene VISTA enhancer mm1622 Neighboring gene STARR-positive B cell enhancer ABC_E5309

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer dynein arm ISM
    Inferred from Sequence Model
    more info
    PubMed 
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dynein axonemal heavy chain 17
    Names
    axonemal beta dynein heavy chain 17
    ciliary dynein heavy chain 17
    dynein heavy chain 17, axonemal
    dynein, axonemal, heavy like 1
    dynein, axonemal, heavy polypeptide 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167746.1NP_001161218.1  dynein axonemal heavy chain 17

      Status: VALIDATED

      Source sequence(s)
      AL591204, AL591433
      Consensus CDS
      CCDS48994.1
      UniProtKB/Swiss-Prot
      O08820, Q69Z23
      UniProtKB/TrEMBL
      E9Q7P0
      Related
      ENSMUSP00000081864.6, ENSMUST00000084803.12
      Conserved Domains (6) summary
      pfam03028
      Location:37504443
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:185764
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12651669
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:30273370
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:33973610
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:24002671
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117912549..118021684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534150.5XP_006534213.1  dynein axonemal heavy chain 17 isoform X1

      UniProtKB/Swiss-Prot
      O08820, Q69Z23
      UniProtKB/TrEMBL
      A2A520
      Related
      ENSMUSP00000120542.3, ENSMUST00000132685.9
      Conserved Domains (7) summary
      COG5245
      Location:14934124
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:30403383
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:187764
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12661672
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18062132
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:27683027
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:41624457
      Dynein_C; Dynein heavy chain C-terminal domain
    2. XM_006534151.4XP_006534214.1  dynein axonemal heavy chain 17 isoform X2

      UniProtKB/Swiss-Prot
      O08820, Q69Z23
      Conserved Domains (7) summary
      COG5245
      Location:9793610
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:25262869
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:2250
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:7521158
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:12921618
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:22542513
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:36483943
      Dynein_C; Dynein heavy chain C-terminal domain
    3. XM_006534152.4XP_006534215.1  dynein axonemal heavy chain 17 isoform X3

      Conserved Domains (5) summary
      pfam08385
      Location:187764
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12661672
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18062132
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam17852
      Location:22912408
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      cl38936
      Location:21202255
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_388524.5 RNA Sequence