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    Ttc7b tetratricopeptide repeat domain 7B [ Mus musculus (house mouse) ]

    Gene ID: 104718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc7bprovided by MGI
    Official Full Name
    tetratricopeptide repeat domain 7Bprovided by MGI
    Primary source
    MGI:MGI:2144724
    See related
    Ensembl:ENSMUSG00000033530 AllianceGenome:MGI:2144724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttc7l1
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; liver; and retina nuclear layer. Orthologous to human TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 38.4), frontal lobe adult (RPKM 33.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc7b in Genome Data Viewer
    Location:
    12 E; 12 50.43 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100267029..100487134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100300770..100520837, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:101466777-101466886 Neighboring gene STARR-seq mESC enhancer starr_33040 Neighboring gene calmodulin 1 Neighboring gene predicted gene, 40557 Neighboring gene STARR-seq mESC enhancer starr_33043 Neighboring gene predicted gene 10432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:101570101-101570302 Neighboring gene STARR-seq mESC enhancer starr_33044 Neighboring gene predicted gene, 51958 Neighboring gene STARR-positive B cell enhancer ABC_E7167 Neighboring gene predicted gene, 53757 Neighboring gene predicted gene, 36375 Neighboring gene STARR-seq mESC enhancer starr_33048 Neighboring gene STARR-positive B cell enhancer ABC_E1450 Neighboring gene STARR-seq mESC enhancer starr_33055 Neighboring gene ribosomal protein S6 kinase, polypeptide 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101842850-101843151 Neighboring gene STARR-seq mESC enhancer starr_33059 Neighboring gene STARR-positive B cell enhancer ABC_E1451 Neighboring gene STARR-positive B cell enhancer ABC_E8499 Neighboring gene predicted gene 2614

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F, et al. J Cell Biol, 2012 Dec 10. PMID 23229899, Free PMC Article
    2. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
    3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 7B
    Names
    TPR repeat protein 7B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033213.2 → NP_001028385.1  tetratricopeptide repeat protein 7B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123705, AC159633, AC160340
      Consensus CDS
      CCDS49141.1
      UniProtKB/Swiss-Prot
      E9Q6P5
      Related
      ENSMUSP00000052107.7, ENSMUST00000062957.8
      Conserved Domains (3) summary
      TIGR02917
      Location:343 → 834
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:431 → 459
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:730 → 758
      TPR; TPR repeat [structural motif]

    2. NM_001374711.1 → NP_001361640.1  tetratricopeptide repeat protein 7B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123705, AC159633, AC160340
      Consensus CDS
      CCDS88387.1
      UniProtKB/TrEMBL
      A0A1Y7VL44
      Related
      ENSMUSP00000152299.2, ENSMUST00000223020.2
      Conserved Domains (4) summary
      TIGR00990
      Location:686 → 859
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:343 → 851
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:431 → 459
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:747 → 775
      TPR; TPR repeat [structural motif]

    3. NM_001401370.1 → NP_001388299.1  tetratricopeptide repeat protein 7B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123705, AC159633, AC160340

    4. NM_001413292.1 → NP_001400221.1  tetratricopeptide repeat protein 7B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123705, AC159633, AC160340

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      100267029..100487134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515326.4 → XP_006515389.1  tetratricopeptide repeat protein 7B isoform X3

      Conserved Domains (4) summary
      COG0457
      Location:365 → 619
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:755 → 928
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:431 → 459
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:816 → 844
      TPR; TPR repeat [structural motif]

    2. XM_017314925.3 → XP_017170414.1  tetratricopeptide repeat protein 7B isoform X10

      Conserved Domains (3) summary
      TIGR02917
      Location:351 → 843
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:739 → 767
      TPR; TPR repeat [structural motif]

    3. XM_017314924.3 → XP_017170413.1  tetratricopeptide repeat protein 7B isoform X9

      Conserved Domains (3) summary
      TIGR02917
      Location:351 → 851
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:747 → 775
      TPR; TPR repeat [structural motif]

    4. XM_017314922.3 → XP_017170411.1  tetratricopeptide repeat protein 7B isoform X8

      Conserved Domains (3) summary
      TIGR02917
      Location:351 → 858
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:754 → 782
      TPR; TPR repeat [structural motif]

    5. XM_017314921.3 → XP_017170410.1  tetratricopeptide repeat protein 7B isoform X7

      Conserved Domains (4) summary
      TIGR00990
      Location:694 → 867
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:351 → 859
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:755 → 783
      TPR; TPR repeat [structural motif]

    6. XM_017314920.3 → XP_017170409.1  tetratricopeptide repeat protein 7B isoform X6

      Conserved Domains (4) summary
      TIGR00990
      Location:702 → 875
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:351 → 867
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:763 → 791
      TPR; TPR repeat [structural motif]

    7. XM_017314919.3 → XP_017170408.1  tetratricopeptide repeat protein 7B isoform X5

      Conserved Domains (4) summary
      TIGR00990
      Location:709 → 882
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:351 → 874
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:770 → 798
      TPR; TPR repeat [structural motif]

    8. XM_006515328.4 → XP_006515391.1  tetratricopeptide repeat protein 7B isoform X4

      Conserved Domains (4) summary
      TIGR00990
      Location:748 → 921
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:351 → 913
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:809 → 837
      TPR; TPR repeat [structural motif]

    9. XM_011243973.4 → XP_011242275.1  tetratricopeptide repeat protein 7B isoform X2

      Conserved Domains (4) summary
      COG0457
      Location:373 → 627
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:756 → 929
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:817 → 845
      TPR; TPR repeat [structural motif]

    10. XM_006515325.2 → XP_006515388.1  tetratricopeptide repeat protein 7B isoform X1

      Conserved Domains (4) summary
      COG0457
      Location:373 → 627
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:763 → 936
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:439 → 467
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:824 → 852
      TPR; TPR repeat [structural motif]

    11. XM_036157145.1 → XP_036013038.1  tetratricopeptide repeat protein 7B isoform X16

      Conserved Domains (4) summary
      TIGR00990
      Location:289 → 462
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:24 → 454
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:51 → 79
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:350 → 378
      TPR; TPR repeat [structural motif]

    12. XM_030246492.1 → XP_030102352.1  tetratricopeptide repeat protein 7B isoform X15

      Conserved Domains (3) summary
      TIGR02917
      Location:85 → 576
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:173 → 201
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:472 → 500
      TPR; TPR repeat [structural motif]

    13. XM_030246491.1 → XP_030102351.1  tetratricopeptide repeat protein 7B isoform X14

      Conserved Domains (4) summary
      COG0457
      Location:107 → 361
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:497 → 670
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:173 → 201
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:558 → 586
      TPR; TPR repeat [structural motif]

    14. XM_030246490.1 → XP_030102350.1  tetratricopeptide repeat protein 7B isoform X13

      Conserved Domains (4) summary
      COG0457
      Location:263 → 517
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:653 → 826
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:329 → 357
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:714 → 742
      TPR; TPR repeat [structural motif]

    15. XM_036157144.1 → XP_036013037.1  tetratricopeptide repeat protein 7B isoform X12

      Conserved Domains (4) summary
      COG0457
      Location:271 → 525
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:661 → 834
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:337 → 365
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:722 → 750
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6P5.1 GenPept UniProtKB/Swiss-Prot:E9Q6P5

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