Wrnip1 Werner helicase interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wrnip1provided by MGI
Official Full Name: Werner helicase interacting protein 1provided by MGI
Primary source: MGI:MGI:1926153
See related: Ensembl:ENSMUSG00000021400 AllianceGenome:MGI:1926153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WHIP; Wrnip; 4833444L21Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA synthesis involved in DNA repair; DNA-templated DNA replication; and regulation of DNA-templated DNA replication initiation. Located in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; cranium; limb; and naris. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 30.0), adrenal adult (RPKM 23.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.2; 13 13.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (32986013..33006593)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (32802030..32822610)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.
Title: Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated DNA replication initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase WRNIP1

Names: Werner helicasae interacting protein 1; Werner syndrome homolog interacting protein; werner helicase-interacting protein 1

NP_084491.3

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030215.3 → NP_084491.3 ATPase WRNIP1

See identical proteins and their annotated locations for NP_084491.3

Status: VALIDATED

Source sequence(s)

AK041886, AK167570, AV237237

Consensus CDS

CCDS26427.1

UniProtKB/Swiss-Prot

Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q91XU0, Q921W3, Q9EQL3

Related

ENSMUSP00000021832.7, ENSMUST00000021832.7

Conserved Domains (5) summary

cd00009
Location:235 → 371

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00734
Location:17 → 40

ZnF_Rad18; Rad18-like CCHC zinc finger

PRK13342
Location:221 → 656

PRK13342; recombination factor protein RarA; Reviewed

pfam12002
Location:507 → 656

MgsA_C; MgsA AAA+ ATPase C terminal

pfam16193
Location:417 → 506

AAA_assoc_2; AAA C-terminal domain