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    Gcnt4 glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 218476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gcnt4provided by MGI
    Official Full Name
    glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)provided by MGI
    Primary source
    MGI:MGI:2684919
    See related
    Ensembl:ENSMUSG00000091387 AllianceGenome:MGI:2684919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm73; Gm279; C2gnt3
    Summary
    Predicted to enable acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including inter-male aggressive behavior; neutrophil homeostasis; and thyroid hormone metabolic process. Predicted to be located in Golgi membrane. Orthologous to human GCNT4 (glucosaminyl (N-acetyl) transferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 8.0), large intestine adult (RPKM 4.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gcnt4 in Genome Data Viewer
    Location:
    13 D1; 13 50.66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97060852..97087422)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96924344..96950914)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33171 Neighboring gene ankyrin repeat domain 31 Neighboring gene predicted gene, 57606 Neighboring gene STARR-seq mESC enhancer starr_35351 Neighboring gene STARR-seq mESC enhancer starr_35353 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97735001-97735184 Neighboring gene predicted gene, 41027 Neighboring gene RIKEN cDNA 1700029F12 gene Neighboring gene predicted gene, 41028

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147. Fan J, et al. Glycoconj J, 2012 Aug. PMID 22736280
    2. High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Ismail MN, et al. Glycobiology, 2011 Jan. PMID 20855471, Free PMC Article
    3. CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner. Lan ZZ, et al. Kaohsiung J Med Sci, 2024 Mar. PMID 38180297
    4. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. Kidder D, et al. J Immunol, 2013 Mar 15. PMID 23408841, Free PMC Article
    5. Requirement for core 2 O-glycans for optimal resistance to helminth infection. Mullaly SC, et al. PLoS One, 2013. PMID 23555902, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.
      Title: CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.
    2. N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
      Title: N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thyroid hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
    Names
    core 2 beta-1,6-N-acetylglucosaminyltransferase 3
    core 2-branching enzyme 3
    core2-GlcNAc-transferase 3
    glucosaminyl (N-acetyl) transferase 3, mucin type pseudogene
    NP_001159537.1
    NP_001363928.1
    XP_006517659.1
    XP_006517660.1
    XP_006517661.1
    XP_006517663.1
    XP_006517664.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166065.2 → NP_001159537.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

      See identical proteins and their annotated locations for NP_001159537.1

      Status: VALIDATED

      Source sequence(s)
      AC174082
      Consensus CDS
      CCDS49336.1
      UniProtKB/Swiss-Prot
      E9Q649
      Related
      ENSMUSP00000130496.2, ENSMUST00000171324.3
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    2. NM_001376999.1 → NP_001363928.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

      Status: VALIDATED

      Source sequence(s)
      AC174082
      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97060852..97087422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517597.3 → XP_006517660.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006517660.1

      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    2. XM_006517598.3 → XP_006517661.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006517661.1

      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    3. XM_006517596.5 → XP_006517659.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006517659.1

      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    4. XM_006517600.2 → XP_006517663.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006517663.1

      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    5. XM_006517601.4 → XP_006517664.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006517664.1

      UniProtKB/Swiss-Prot
      E9Q649
      Conserved Domains (1) summary
      cl27418
      Location:134 → 402
      Branch; Core-2/I-Branching enzyme

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019525.1: Suppressed sequence

      Description
      NG_019525.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q649.1 GenPept UniProtKB/Swiss-Prot:E9Q649

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