Mylk4 myosin light chain kinase family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mylk4provided by MGI
Official Full Name: myosin light chain kinase family, member 4provided by MGI
Primary source: MGI:MGI:3643758
See related: Ensembl:ENSMUSG00000044951 AllianceGenome:MGI:3643758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG238564
Summary: Predicted to enable myosin light chain kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Orthologous to human MYLK4 (myosin light chain kinase family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 15.6), mammary gland adult (RPKM 3.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 13 A3.2; 13 13.72 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (32884807..32967947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (32700824..32806773, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In contrast to smooth muscle MLCK and skeletal muscle MLCK, which lack activity in the absence of Ca(2+)/calmodulin, cardiac MLCK has constitutive activity that is stimulated by Ca(2+)/calmodulin.
Title: Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

D13Cwr2 (e-PCR), detects polymorphism
- UniSTS:141880

RH126207 (e-PCR)
- UniSTS:162915

D13Mit265 (e-PCR), detects polymorphism
- UniSTS:127082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables myosin light chain kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin light chain kinase family member 4

Names: sgK085; sugen kinase 85

NP_001355809.1

EC 2.7.11.1

NP_001413568.1

EC 2.7.11.1

XP_006516731.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368880.1 → NP_001355809.1 myosin light chain kinase family member 4 isoform 1

Status: VALIDATED

Source sequence(s)

AL645808

UniProtKB/TrEMBL

A0A5F8MPR5

Related

ENSMUSP00000159085.3, ENSMUST00000238977.3

Conserved Domains (1) summary

cl21453
Location:339 → 599

PKc_like; Protein Kinases, catalytic domain
NM_001426639.1 → NP_001413568.1 myosin light chain kinase family member 4 isoform 2

Status: VALIDATED

Source sequence(s)

AL645808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

32884807..32967947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516668.5 → XP_006516731.1 myosin light chain kinase family member 4 isoform X1

UniProtKB/TrEMBL

A0A5F8MPR5

Conserved Domains (1) summary

cd14193
Location:371 → 631

STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001166030.1: Suppressed sequence

Description

NM_001166030.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.