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    Rhpn1 rhophilin, Rho GTPase binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14787, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rhpn1provided by MGI
    Official Full Name
    rhophilin, Rho GTPase binding protein 1provided by MGI
    Primary source
    MGI:MGI:1098783
    See related
    Ensembl:ENSMUSG00000022580 AllianceGenome:MGI:1098783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grbp; Rhophilin; mKIAA1929
    Summary
    Acts upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hindlimb digit mesenchyme; musculoskeletal system; nervous system; and retina nuclear layer. Orthologous to human RHPN1 (rhophilin Rho GTPase binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 16.0), kidney adult (RPKM 15.8) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rhpn1 in Genome Data Viewer
    Location:
    15 D3; 15 34.76 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75576097..75586268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75704246..75714419)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810039B14 gene Neighboring gene VISTA enhancer mm1304 Neighboring gene DNA topoisomerase 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E4136 Neighboring gene STARR-positive B cell enhancer ABC_E10864 Neighboring gene MAF bZIP transcription factor A Neighboring gene zinc finger CCCH type containing 3 Neighboring gene predicted gene, 23747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1929

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    rhophilin-1
    Names
    GTP-Rho-binding protein 1
    GTP-rho binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163465.2NP_001156937.1  rhophilin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116393
      Consensus CDS
      CCDS49641.1
      UniProtKB/TrEMBL
      E9Q7Q7, Q5DTT9
      Related
      ENSMUSP00000113042.2, ENSMUST00000121137.9
      Conserved Domains (3) summary
      cd09248
      Location:116498
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      cd11633
      Location:28112
      HR1_Rhophilin-1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1
      cd00992
      Location:519593
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001411251.1NP_001398180.1  rhophilin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116393
      UniProtKB/TrEMBL
      Q5DTT9
    3. NM_008164.3NP_032190.2  rhophilin-1 isoform 2

      See identical proteins and their annotated locations for NP_032190.2

      Status: VALIDATED

      Source sequence(s)
      AC116393
      Consensus CDS
      CCDS27548.1
      UniProtKB/Swiss-Prot
      E9QMX9, Q61085
      UniProtKB/TrEMBL
      Q5DTT9
      Related
      ENSMUSP00000023244.6, ENSMUST00000023244.6
      Conserved Domains (3) summary
      cd09248
      Location:116498
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      cd11633
      Location:28112
      HR1_Rhophilin-1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1
      cd00992
      Location:501575
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75576097..75586268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316433.3XP_017171922.1  rhophilin-1 isoform X2

      Conserved Domains (2) summary
      cd00992
      Location:290364
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14649
      Location:3269
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
    2. XM_017316434.2XP_017171923.1  rhophilin-1 isoform X3

      Conserved Domains (2) summary
      cd00992
      Location:289363
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14649
      Location:3268
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains