U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bik BCL2-interacting killer [ Mus musculus (house mouse) ]

    Gene ID: 12124, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bikprovided by MGI
    Official Full Name
    BCL2-interacting killerprovided by MGI
    Primary source
    MGI:MGI:1206591
    See related
    Ensembl:ENSMUSG00000016758 AllianceGenome:MGI:1206591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blk; Nbk; Biklk
    Summary
    Predicted to enable BH domain binding activity. Acts upstream of or within apoptotic mitochondrial changes; male gonad development; and spermatogenesis. Located in mitochondrial envelope. Is expressed in several structures, including genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 4.3), colon adult (RPKM 3.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bik in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83410992..83428836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83526790..83544635)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1 Neighboring gene predicted gene, 46495 Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene translocator protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bcl-2-interacting killer
    Names
    apoptosis inducer NBK
    bik-like killer protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007546.2NP_031572.1  bcl-2-interacting killer

      See identical proteins and their annotated locations for NP_031572.1

      Status: PROVISIONAL

      Source sequence(s)
      AL583889
      Consensus CDS
      CCDS27703.1
      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Related
      ENSMUSP00000016902.4, ENSMUST00000016902.5
      Conserved Domains (1) summary
      pfam12201
      Location:1149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83410992..83428836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520354.5XP_006520417.1  bcl-2-interacting killer isoform X2

      UniProtKB/TrEMBL
      Q99L97
      Conserved Domains (1) summary
      pfam12201
      Location:34182
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing
    2. XM_006520355.3XP_006520418.1  bcl-2-interacting killer isoform X3

      See identical proteins and their annotated locations for XP_006520418.1

      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Related
      ENSMUSP00000155439.2, ENSMUST00000229165.2
      Conserved Domains (1) summary
      pfam12201
      Location:1149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing
    3. XM_006520356.2XP_006520419.1  bcl-2-interacting killer isoform X3

      See identical proteins and their annotated locations for XP_006520419.1

      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Conserved Domains (1) summary
      pfam12201
      Location:1149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing
    4. XM_006520353.4XP_006520416.1  bcl-2-interacting killer isoform X1

      Conserved Domains (1) summary
      pfam12201
      Location:60208
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing