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    Tspo translocator protein [ Mus musculus (house mouse) ]

    Gene ID: 12257, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tspoprovided by MGI
    Official Full Name
    translocator proteinprovided by MGI
    Primary source
    MGI:MGI:88222
    See related
    Ensembl:ENSMUSG00000041736 AllianceGenome:MGI:88222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IBP; PBR; Bzrp; Tspo1
    Summary
    Enables transmembrane transporter binding activity. Involved in several processes, including negative regulation of ATP metabolic process; negative regulation of mitophagy; and protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; reproductive system; and sensory organ. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 621.7), mammary gland adult (RPKM 396.5) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tspo in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83447774..83458404)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83563573..83574203)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46495 Neighboring gene BCL2-interacting killer Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene tubulin tyrosine ligase-like family, member 12 Neighboring gene STARR-positive B cell enhancer ABC_E8602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:83433173-83433433 Neighboring gene predicted gene, 52182 Neighboring gene signal peptide, CUB domain, EGF-like 1 Neighboring gene VISTA enhancer mm84 Neighboring gene Scube1 Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_39342 Neighboring gene predicted gene, 52183

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables androgen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables androgen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables benzodiazepine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables benzodiazepine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hypotonic response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in contact inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ATP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of corticosterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of corticosterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peripheral nervous system axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of programmed necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to acetylcholine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to manganese ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin B1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    translocator protein
    Names
    PKBS
    benzodiazepine receptor, peripheral
    isoquinoline-binding protein
    mitochondrial benzodiazepine receptor
    peripheral-type benzodiazepine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009775.4NP_033905.3  translocator protein

      See identical proteins and their annotated locations for NP_033905.3

      Status: VALIDATED

      Source sequence(s)
      AA472650, AI841615, AK153273
      Consensus CDS
      CCDS27705.1
      UniProtKB/Swiss-Prot
      P50637, Q541E3, Q62118, Q6LCZ0, Q99M32
      Related
      ENSMUSP00000037039.7, ENSMUST00000047419.8
      Conserved Domains (1) summary
      pfam03073
      Location:12155
      TspO_MBR; TspO/MBR family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83447774..83458404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)