Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpd1provided by MGI
Official Full Name: glycerol-3-phosphate dehydrogenase 1 (soluble)provided by MGI
Primary source: MGI:MGI:95679
See related: Ensembl:ENSMUSG00000023019 AllianceGenome:MGI:95679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gdc1; GPD-C; Gdc-1; GPDH-C
Summary: Enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in glycerophosphate shuttle. Acts upstream of or within several processes, including cellular response to cAMP; gluconeogenesis; and positive regulation of glycolytic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver; and nervous system. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 391.7), subcutaneous fat pad adult (RPKM 371.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.13 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (99615468..99622895)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99717587..99725014)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.
Title: Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.
The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice.
Title: The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice.
GPD1 null mice showed increased exercise capacity. Exercise-induced lipid oxidation was enhanced in GPD1 null mice.
Title: Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.
GPD1 and glycolytic gene expression is up-regulated by ethanol, and GPD1-mediated incorporation of glucose into triglycerides glycerol moieties together with increased lipogenesis plays a role in ethanol-induced hepatic triglycerides accumulation.
Title: The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.
Knockout mice deficient in both cytosolic and mitochondrial GPD have lethal hypoglycemic ketosis and glyceroluria.
Title: Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpd1 (e-PCR), detects polymorphism
- UniSTS:527364

D15Mit14 (e-PCR), detects polymorphism
- UniSTS:127502

Gdc1 (e-PCR), detects polymorphism
- UniSTS:143189

D10Bir3 (e-PCR), detects polymorphism
- UniSTS:141483

22.MMHAP28FLH1.seq (e-PCR)
- UniSTS:123565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NADH oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NADH oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycerol-3-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerolipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycerophosphate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerophosphate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Names: glycerolphosphate dehydrogenase 1, cytoplasmic adult

NP_034401.1

EC 1.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010271.3 → NP_034401.1 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

See identical proteins and their annotated locations for NP_034401.1

Status: VALIDATED

Source sequence(s)

AK018733, AK137134

Consensus CDS

CCDS27828.1

UniProtKB/Swiss-Prot

P13707, Q3UVM3, Q5DTS5

UniProtKB/TrEMBL

E0CXN5

Related

ENSMUSP00000023760.7, ENSMUST00000023760.13

Conserved Domains (3) summary

TIGR03376
Location:5 → 342

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

pfam01210
Location:5 → 172

NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

pfam07479
Location:194 → 335

NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus