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    Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [ Mus musculus (house mouse) ]

    Gene ID: 23970, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pacsin2provided by MGI
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 2provided by MGI
    Primary source
    MGI:MGI:1345153
    See related
    Ensembl:ENSMUSG00000016664 AllianceGenome:MGI:1345153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SdpII
    Summary
    Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; cerebral cortex ventricular layer; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 34.6), kidney adult (RPKM 33.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pacsin2 in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83259812..83348800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83375607..83464610, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ARF GTPase activating protein 3 Neighboring gene RIKEN cDNA 1700001L05 gene Neighboring gene microRNA 12186 Neighboring gene predicted gene, 41368 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2449 Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in caveola assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveolin-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 2
    Names
    Syndapin II
    syndapin-2
    syndapin-II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159509.2NP_001152981.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152981.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000131504.2, ENSMUST00000171436.8
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348428
      NPF; Rabosyn-5 repeating NPF sequence-motif
    2. NM_001159510.2NP_001152982.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152982.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000155334.2, ENSMUST00000231184.2
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348428
      NPF; Rabosyn-5 repeating NPF sequence-motif
    3. NM_001358641.2NP_001345570.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    4. NM_001358642.2NP_001345571.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    5. NM_001358643.2NP_001345572.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:388443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    6. NM_001358644.2NP_001345573.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    7. NM_001411850.1NP_001398779.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
    8. NM_001411851.1NP_001398780.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
    9. NM_001411852.1NP_001398781.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
    10. NM_011862.4NP_035992.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035992.1

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7
      Related
      ENSMUSP00000130098.2, ENSMUST00000165095.9
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:348428
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RNA

    1. NR_177947.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165945, AL583889

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83259812..83348800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245633.4XP_011243935.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243935.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    2. XM_006520981.4XP_006521044.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521044.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    3. XM_036159409.1XP_036015302.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    4. XM_006520980.4XP_006521043.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521043.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    5. XM_006520983.5XP_006521046.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521046.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    6. XM_006520982.2XP_006521045.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521045.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:342430
      NPF; Rabosyn-5 repeating NPF sequence-motif