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    Ttll1 tubulin tyrosine ligase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 319953, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttll1provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like 1provided by MGI
    Primary source
    MGI:MGI:2443047
    See related
    Ensembl:ENSMUSG00000022442 AllianceGenome:MGI:2443047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330444E16Rik
    Summary
    Enables tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Located in ciliary basal body. Is expressed in 1-cell stage embryo; 8-cell stage embryo; blastocyst; and cortical plate. Used to study primary ciliary dyskinesia. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 14.5), CNS E18 (RPKM 14.3) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ttll1 in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83367258..83402675, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83483057..83518474, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2449 Neighboring gene predicted gene, 52181 Neighboring gene predicted gene, 46495 Neighboring gene BCL2-interacting killer Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-glutamic acid ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin-glutamic acid ligase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin-glutamic acid ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    polyglutamylase complex subunit TTLL1
    Names
    PGs3
    p49
    probable tubulin polyglutamylase TTLL1
    tubulin polyglutamylase TTLL1
    tubulin polyglutamylase complex subunit 3
    tubulin--tyrosine ligase-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357953.1NP_001344882.1  polyglutamylase complex subunit TTLL1

      Status: VALIDATED

      Source sequence(s)
      AL583889
      Consensus CDS
      CCDS27702.1
      UniProtKB/Swiss-Prot
      Q3TGC8, Q543S4, Q8C0A2, Q91V51, Q91ZG1
      Conserved Domains (1) summary
      pfam03133
      Location:59364
      TTL; Tubulin-tyrosine ligase family
    2. NM_178869.4NP_849200.2  polyglutamylase complex subunit TTLL1

      See identical proteins and their annotated locations for NP_849200.2

      Status: VALIDATED

      Source sequence(s)
      AK140472, AK168786, AK169150, BY091756
      Consensus CDS
      CCDS27702.1
      UniProtKB/Swiss-Prot
      Q3TGC8, Q543S4, Q8C0A2, Q91V51, Q91ZG1
      Related
      ENSMUSP00000016897.5, ENSMUST00000016897.12
      Conserved Domains (1) summary
      pfam03133
      Location:59364
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83367258..83402675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248606.2XP_030104466.1  polyglutamylase complex subunit TTLL1 isoform X2

      Conserved Domains (1) summary
      pfam03133
      Location:2264
      TTL; Tubulin-tyrosine ligase family
    2. XM_006521078.4XP_006521141.1  polyglutamylase complex subunit TTLL1 isoform X1

      See identical proteins and their annotated locations for XP_006521141.1

      UniProtKB/Swiss-Prot
      Q3TGC8, Q543S4, Q8C0A2, Q91V51, Q91ZG1
      Conserved Domains (1) summary
      pfam03133
      Location:59364
      TTL; Tubulin-tyrosine ligase family