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    Adcyap1 adenylate cyclase activating polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 11516, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adcyap1provided by MGI
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by MGI
    Primary source
    MGI:MGI:105094
    See related
    Ensembl:ENSMUSG00000024256 AllianceGenome:MGI:105094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PACAP
    Summary
    This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in CNS E18 (RPKM 2.0), CNS E14 (RPKM 1.8) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adcyap1 in Genome Data Viewer
    Location:
    17 E5; 17 60.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (93506448..93513967)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (93198245..93206541)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53959 Neighboring gene STARR-seq mESC enhancer starr_43615 Neighboring gene STARR-seq mESC enhancer starr_43616 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_43617 Neighboring gene STARR-seq mESC enhancer starr_43618 Neighboring gene STARR-seq mESC enhancer starr_43619 Neighboring gene STARR-seq mESC enhancer starr_43620 Neighboring gene STARR-seq mESC enhancer starr_43621 Neighboring gene predicted gene, 32465 Neighboring gene predicted gene, 25935 Neighboring gene ribosomal protein L3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pituitary adenylate cyclase activating polypeptide activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pituitary adenylate cyclase-activating polypeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pituitary adenylate cyclase-activating polypeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 vasoactive intestinal polypeptide receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables type 2 vasoactive intestinal polypeptide receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of acute inflammatory response to non-antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of acute inflammatory response to non-antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of somatostatin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of oligodendrocyte progenitor proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of oligodendrocyte progenitor proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal dense core vesicle lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001315503.2NP_001302432.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC154798
      Consensus CDS
      CCDS29029.1
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
      Related
      ENSMUSP00000157279.2, ENSMUST00000234081.2
      Conserved Domains (1) summary
      pfam00123
      Location:131158
      Hormone_2; Peptide hormone
    2. NM_001315504.2NP_001302433.1  pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154798
      UniProtKB/TrEMBL
      Q8BJT8
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    3. NM_001409525.1NP_001396454.1  pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154798
      UniProtKB/TrEMBL
      Q8BJT8
    4. NM_001409527.1NP_001396456.1  pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154798
      UniProtKB/TrEMBL
      Q8BJT8
    5. NM_001409528.1NP_001396457.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154798
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
    6. NM_001409530.1NP_001396459.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154798
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
    7. NM_001409531.1NP_001396460.1  pituitary adenylate cyclase-activating polypeptide isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154798
    8. NM_001409532.1NP_001396461.1  pituitary adenylate cyclase-activating polypeptide isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154798
    9. NM_001412216.1NP_001399145.1  pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154798
      UniProtKB/TrEMBL
      Q8BJT8
    10. NM_009625.4NP_033755.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC154798
      Consensus CDS
      CCDS29029.1
      UniProtKB/Swiss-Prot
      O70176
      UniProtKB/TrEMBL
      Q3UYH8, Q8BJT8
      Related
      ENSMUSP00000067057.7, ENSMUST00000064775.8
      Conserved Domains (1) summary
      pfam00123
      Location:131158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      93506448..93513967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)