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    Rab11fip3 RAB11 family interacting protein 3 (class II) [ Mus musculus (house mouse) ]

    Gene ID: 215445, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rab11fip3provided by MGI
    Official Full Name
    RAB11 family interacting protein 3 (class II)provided by MGI
    Primary source
    MGI:MGI:2444431
    See related
    Ensembl:ENSMUSG00000037098 AllianceGenome:MGI:2444431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FIP3; Cart1; mKIAA0665; Rab11-FIP3; D030060O14Rik
    Summary
    Predicted to enable several functions, including dynein light intermediate chain binding activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within protein localization to cilium. Located in membrane. Is active in postsynaptic recycling endosome membrane. Is expressed in several structures, including gonad; gut; immune system; liver; and retina. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 86.1), frontal lobe adult (RPKM 15.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rab11fip3 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.05 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26208010..26289010, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25989036..26070077, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene proline rich 35 Neighboring gene calpain 15 Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1937 Neighboring gene STARR-seq mESC enhancer starr_42116 Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene Neighboring gene 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC47508

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein light intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein light intermediate chain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to recycling endosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to recycling endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of adiponectin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adiponectin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cytokinetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of early endosome to recycling endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of early endosome to recycling endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    rab11 family-interacting protein 3
    Names
    FIP3-Rab11
    cytoplasmic adaptor for RAR and TR
    NP_001156340.1
    NP_001156341.1
    NP_694780.1
    XP_011244664.1
    XP_036016358.1
    XP_036016359.1
    XP_036016360.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162868.2NP_001156340.1  rab11 family-interacting protein 3 isoform b

      See identical proteins and their annotated locations for NP_001156340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, that results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC140047, AC159277
      Consensus CDS
      CCDS50040.1
      UniProtKB/Swiss-Prot
      Q8CHD8, Q8JZT3
      Related
      ENSMUSP00000112875.2, ENSMUST00000120691.9
      Conserved Domains (7) summary
      cd00051
      Location:500557
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09457
      Location:10071047
      RBD-FIP; FIP domain
      pfam05700
      Location:770880
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam07926
      Location:831979
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam13499
      Location:501557
      EF-hand_7; EF-hand domain pair
      pfam14077
      Location:938981
      WD40_alt; Alternative WD40 repeat motif
      cl00143
      Location:831933
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    2. NM_001162869.2NP_001156341.1  rab11 family-interacting protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC140047, AC159277
      Consensus CDS
      CCDS50041.1
      UniProtKB/Swiss-Prot
      Q8CHD8
      Related
      ENSMUSP00000113521.2, ENSMUST00000122103.9
      Conserved Domains (7) summary
      cd00051
      Location:500557
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09457
      Location:10521092
      RBD-FIP; FIP domain
      pfam05700
      Location:815925
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam07926
      Location:8761024
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam13499
      Location:501557
      EF-hand_7; EF-hand domain pair
      pfam14077
      Location:9831026
      WD40_alt; Alternative WD40 repeat motif
      cl00143
      Location:876978
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    3. NM_153140.2NP_694780.1  rab11 family-interacting protein 3 isoform c

      See identical proteins and their annotated locations for NP_694780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a distinct 5' UTR and lacks many exons of the 5' coding region, compared to variant 1, that results in a protein (isoform c) that starts from an internal methionine, compared to isoform a.
      Source sequence(s)
      AK083658, AK085516, BE853781, BM114891, CB840427, CF170100, CF747684
      Consensus CDS
      CCDS50039.1
      UniProtKB/Swiss-Prot
      Q8CHD8
      Related
      ENSMUSP00000113048.2, ENSMUST00000118828.8
      Conserved Domains (3) summary
      pfam09457
      Location:404444
      RBD-FIP; FIP domain
      pfam05700
      Location:167277
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      cl19219
      Location:251330
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26208010..26289010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160467.1XP_036016360.1  rab11 family-interacting protein 3 isoform X3

      Conserved Domains (3) summary
      PTZ00449
      Location:12331
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:7961059
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13499
      Location:500557
      EF-hand_7; EF-hand domain pair
    2. XM_036160466.1XP_036016359.1  rab11 family-interacting protein 3 isoform X2

      Conserved Domains (3) summary
      PTZ00449
      Location:12331
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:8081071
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13499
      Location:500557
      EF-hand_7; EF-hand domain pair
    3. XM_036160465.1XP_036016358.1  rab11 family-interacting protein 3 isoform X1

      Conserved Domains (3) summary
      PTZ00449
      Location:12331
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:8531116
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13499
      Location:500557
      EF-hand_7; EF-hand domain pair
    4. XM_011246362.4XP_011244664.1  rab11 family-interacting protein 3 isoform X4

      Conserved Domains (2) summary
      PTZ00449
      Location:12331
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam13499
      Location:500557
      EF-hand_7; EF-hand domain pair

    RNA

    1. XR_876466.3 RNA Sequence