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    Lypd6b LY6/PLAUR domain containing 6B [ Mus musculus (house mouse) ]

    Gene ID: 71897, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lypd6bprovided by MGI
    Official Full Name
    LY6/PLAUR domain containing 6Bprovided by MGI
    Primary source
    MGI:MGI:1919147
    See related
    Ensembl:ENSMUSG00000026765 AllianceGenome:MGI:1919147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310010M24Rik
    Summary
    Predicted to enable acetylcholine receptor regulator activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; notochord; and urinary system. Orthologous to human LYPD6B (LY6/PLAUR domain containing 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 3.8), cortex adult (RPKM 2.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lypd6b in Genome Data Viewer
    Location:
    2 C1.1; 2 28.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49677380..49838861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49787340..49948849)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49307666-49307775 Neighboring gene STARR-positive B cell enhancer ABC_E807 Neighboring gene STARR-seq mESC enhancer starr_04442 Neighboring gene enhancer of polycomb homolog 2 Neighboring gene kinesin family member 5C Neighboring gene STARR-positive B cell enhancer mm9_chr2:49589986-49590287 Neighboring gene STARR-seq mESC enhancer starr_04444 Neighboring gene predicted gene, 46738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49672814-49673015 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49703331-49703484 Neighboring gene STARR-seq mESC enhancer starr_04445 Neighboring gene LY6/PLAUR domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E5915 Neighboring gene STARR-positive B cell enhancer ABC_E9514 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria Neighboring gene predicted gene 13483

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum. Bychkov ML, et al. Dokl Biochem Biophys, 2023 Aug. PMID 37833597
    2. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
      Title: Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143485

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylcholine receptor regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ly6/PLAUR domain-containing protein 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379381.1 → NP_001366310.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    2. NM_001379382.1 → NP_001366311.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    3. NM_001379383.1 → NP_001366312.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    4. NM_001379384.1 → NP_001366313.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    5. NM_001379385.1 → NP_001366314.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    6. NM_001379386.1 → NP_001366315.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    7. NM_001379387.1 → NP_001366316.1  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    8. NM_027990.4 → NP_082266.2  ly6/PLAUR domain-containing protein 6B precursor

      Status: VALIDATED

      Source sequence(s)
      AL806528, AL929069, BX813318
      Consensus CDS
      CCDS16025.1
      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Related
      ENSMUSP00000028103.8, ENSMUST00000028103.13
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      49677380..49838861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498352.5 → XP_006498415.1  ly6/PLAUR domain-containing protein 6B isoform X1

      See identical proteins and their annotated locations for XP_006498415.1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    2. XM_006498350.5 → XP_006498413.1  ly6/PLAUR domain-containing protein 6B isoform X1

      See identical proteins and their annotated locations for XP_006498413.1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    3. XM_006498351.5 → XP_006498414.1  ly6/PLAUR domain-containing protein 6B isoform X1

      See identical proteins and their annotated locations for XP_006498414.1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    4. XM_006498353.5 → XP_006498416.1  ly6/PLAUR domain-containing protein 6B isoform X1

      See identical proteins and their annotated locations for XP_006498416.1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    5. XM_006498354.5 → XP_006498417.1  ly6/PLAUR domain-containing protein 6B isoform X1

      See identical proteins and their annotated locations for XP_006498417.1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    6. XM_017319267.1 → XP_017174756.1  ly6/PLAUR domain-containing protein 6B isoform X1

      UniProtKB/Swiss-Prot
      Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:59 → 163
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

    7. XM_006498359.5 → XP_006498422.1  ly6/PLAUR domain-containing protein 6B isoform X2

      See identical proteins and their annotated locations for XP_006498422.1

      UniProtKB/Swiss-Prot
      A0JNT6, Q9D7F2
      Conserved Domains (1) summary
      pfam16975
      Location:40 → 144
      UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7F2.2 GenPept UniProtKB/Swiss-Prot:Q9D7F2

    Gene LinkOut

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