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    Arhgef16 Rho guanine nucleotide exchange factor 16 [ Mus musculus (house mouse) ]

    Gene ID: 230972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef16provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 16provided by MGI
    Primary source
    MGI:MGI:2446219
    See related
    Ensembl:ENSMUSG00000029032 AllianceGenome:MGI:2446219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Predicted to be located in cytoplasm. Is expressed in several structures, including branchial arch; chordamesoderm; embryo ectoderm; extraembryonic component; and otocyst. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 48.9), duodenum adult (RPKM 48.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef16 in Genome Data Viewer
    Location:
    4 E2; 4 83.96 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154362926..154384535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154278469..154300107, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene transformation related protein 63 regulated 1 like Neighboring gene multiple EGF-like-domains 6 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene predicted gene, 52687 Neighboring gene STARR-seq mESC enhancer starr_12232 Neighboring gene PR domain containing 16 Neighboring gene VISTA enhancer mm1087 Neighboring gene STARR-seq mESC enhancer starr_12235 Neighboring gene predicted gene, 52688 Neighboring gene predicted gene 13133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Lee J, et al. Biochim Biophys Acta, 2014 Nov. PMID 25063526
    2. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
    3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 16
    Names
    Neuroblastoma
    Rho guanine nucleotide exchange factor (GEF) 16
    ephexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112744.1 → NP_001106215.1  rho guanine nucleotide exchange factor 16

      See identical proteins and their annotated locations for NP_001106215.1

      Status: PROVISIONAL

      Source sequence(s)
      AK042195, AK153708
      Consensus CDS
      CCDS51399.1
      UniProtKB/Swiss-Prot
      B1ASH6, Q3U5C8, Q501M8, Q8VCE8
      Related
      ENSMUSP00000030898.6, ENSMUST00000030898.12
      Conserved Domains (3) summary
      cd11938
      Location:637 → 688
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:493 → 626
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:292 → 470
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154362926..154384535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250242.4 → XP_011248544.1  rho guanine nucleotide exchange factor 16 isoform X2

      See identical proteins and their annotated locations for XP_011248544.1

      UniProtKB/Swiss-Prot
      B1ASH6, Q3U5C8, Q501M8, Q8VCE8
      Conserved Domains (3) summary
      cd11938
      Location:637 → 688
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:493 → 626
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:292 → 470
      RhoGEF; RhoGEF domain

    2. XM_006538829.5 → XP_006538892.1  rho guanine nucleotide exchange factor 16 isoform X2

      See identical proteins and their annotated locations for XP_006538892.1

      UniProtKB/Swiss-Prot
      B1ASH6, Q3U5C8, Q501M8, Q8VCE8
      Conserved Domains (3) summary
      cd11938
      Location:637 → 688
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:493 → 626
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:292 → 470
      RhoGEF; RhoGEF domain

    3. XM_011250241.4 → XP_011248543.1  rho guanine nucleotide exchange factor 16 isoform X1

      Conserved Domains (3) summary
      cd11938
      Location:645 → 696
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:501 → 634
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:300 → 478
      RhoGEF; RhoGEF domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U5C8.3 GenPept UniProtKB/Swiss-Prot:Q3U5C8

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