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    Ppp6c protein phosphatase 6, catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 67857, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp6cprovided by MGI
    Official Full Name
    protein phosphatase 6, catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1915107
    See related
    Ensembl:ENSMUSG00000026753 AllianceGenome:MGI:1915107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp6C; 2310003C10Rik
    Summary
    Enables protein serine/threonine phosphatase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.6), bladder adult (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp6c in Genome Data Viewer
    Location:
    2 B; 2 24.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (39084381..39116361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39194369..39226349, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3372 Neighboring gene STARR-seq mESC enhancer starr_04346 Neighboring gene STARR-seq mESC enhancer starr_04347 Neighboring gene vomeronasal 2, receptor, pseudogene 2 Neighboring gene predicted gene, 57696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis. Ogoh H, et al. Mech Dev, 2016 Feb. PMID 26868000
    2. Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Shen Y, et al. Cell Death Dis, 2011 Dec 8. PMID 22158480, Free PMC Article
    3. Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Hayashi K, et al. Oncogene, 2015 Aug 27. PMID 25486434
    4. PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features. Fukui K, et al. Cancer Sci, 2022 May. PMID 35247012, Free PMC Article
    5. Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis. Kishimoto K, et al. Cancer Med, 2021 Jul. PMID 34145991, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.
      Title: Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.
    2. Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
      Title: Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
    3. Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.
      Title: Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.
    4. Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
      Title: Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
    5. PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
      Title: PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
    6. Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
      Title: Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
    7. Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis.
      Title: Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis.
    8. Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
      Title: Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
    9. Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
      Title: Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
    10. Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion
      Title: Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras(G12D) -driven tumor promotion.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 catalytic subunit
    NP_077171.1
    XP_006498319.1
    XP_017174716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024209.3 → NP_077171.1  serine/threonine-protein phosphatase 6 catalytic subunit

      See identical proteins and their annotated locations for NP_077171.1

      Status: VALIDATED

      Source sequence(s)
      AK002764, AK009104, BE634938, BY197919, CD546325
      Consensus CDS
      CCDS16017.1
      UniProtKB/Swiss-Prot
      A2ASL7, Q9CQR6
      Related
      ENSMUSP00000028087.4, ENSMUST00000028087.6
      Conserved Domains (1) summary
      cd07415
      Location:5 → 289
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      39084381..39116361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498256.4 → XP_006498319.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006498319.1

      Conserved Domains (1) summary
      cl13995
      Location:1 → 211
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    2. XM_017319227.3 → XP_017174716.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

      Conserved Domains (1) summary
      cl13995
      Location:45 → 207
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQR6.1 GenPept UniProtKB/Swiss-Prot:Q9CQR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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