U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tgm5 transglutaminase 5 [ Mus musculus (house mouse) ]

    Gene ID: 74176, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tgm5provided by MGI
    Official Full Name
    transglutaminase 5provided by MGI
    Primary source
    MGI:MGI:1921426
    See related
    Ensembl:ENSMUSG00000053675 AllianceGenome:MGI:1921426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGx; TGMX; TGase-5; 2310007C07Rik
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in peeling skin syndrome 2. Orthologous to human TGM5 (transglutaminase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 1.0), cerebellum adult (RPKM 0.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tgm5 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120876591..120916322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121046111..121085841, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cyclin D-type binding-protein 1 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene STARR-seq mESC enhancer starr_05521 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 7 Neighboring gene predicted gene, 23858

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Clone Names

    • MGC143848, MGC143849

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein-glutamine gamma-glutamyltransferase 5
    NP_001349653.1
    NP_083075.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362724.2NP_001349653.1  protein-glutamine gamma-glutamyltransferase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844548
      Conserved Domains (2) summary
      smart00460
      Location:57134
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:390487
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    2. NM_028799.4NP_083075.1  protein-glutamine gamma-glutamyltransferase 5 isoform 1

      See identical proteins and their annotated locations for NP_083075.1

      Status: VALIDATED

      Source sequence(s)
      AL844548
      Consensus CDS
      CCDS16632.1
      UniProtKB/Swiss-Prot
      A2AQ62, Q3V1F9, Q9D7I9
      UniProtKB/TrEMBL
      Q14B90, Q14B91
      Related
      ENSMUSP00000028721.8, ENSMUST00000028721.8
      Conserved Domains (3) summary
      smart00460
      Location:275368
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:11126
      Transglut_N; Transglutaminase family
      pfam00927
      Location:624721
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120876591..120916322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)