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    Arsj arylsulfatase J [ Mus musculus (house mouse) ]

    Gene ID: 271970, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arsjprovided by MGI
    Official Full Name
    arylsulfatase Jprovided by MGI
    Primary source
    MGI:MGI:2443513
    See related
    Ensembl:ENSMUSG00000046561 AllianceGenome:MGI:2443513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D830047F08; 9330196J05Rik
    Summary
    Predicted to enable metal ion binding activity and sulfuric ester hydrolase activity. Predicted to be located in actin cytoskeleton. Is expressed in Meckel's cartilage; elbow joint primordium; otic capsule; and vertebral cartilage condensation. Orthologous to human ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 1.9), bladder adult (RPKM 1.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arsj in Genome Data Viewer
    Location:
    3 G1; 3 55.97 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (126157566..126234025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (126363852..126440374)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40146 Neighboring gene STARR-seq mESC enhancer starr_08928 Neighboring gene STARR-seq mESC enhancer starr_08929 Neighboring gene family with sequence similarity 98, member B pseudogene Neighboring gene STARR-seq mESC enhancer starr_08930 Neighboring gene predicted gene, 35408 Neighboring gene STARR-seq mESC enhancer starr_08931 Neighboring gene STARR-seq mESC enhancer starr_08932 Neighboring gene STARR-seq mESC enhancer starr_08933 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46823 Neighboring gene STARR-seq mESC enhancer starr_08934 Neighboring gene STARR-seq mESC enhancer starr_08935

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of sulfatase genes in the developing mouse embryo. Ratzka A, et al. Dev Dyn, 2010 Jun. PMID 20503373
    2. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
    3. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arylsulfatase J
    Names
    ASJ
    NP_775627.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173451.4 → NP_775627.1  arylsulfatase J precursor

      See identical proteins and their annotated locations for NP_775627.1

      Status: VALIDATED

      Source sequence(s)
      AC091322, AC114551
      Consensus CDS
      CCDS17822.1
      UniProtKB/Swiss-Prot
      Q8BKG5, Q8BL46, Q8BM89
      UniProtKB/TrEMBL
      Q32KI8, Q8BM79
      Related
      ENSMUSP00000091511.3, ENSMUST00000093976.4
      Conserved Domains (3) summary
      COG3119
      Location:71 → 507
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:74 → 507
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
      cl20644
      Location:493 → 531
      DUF4976; Domain of unknown function (DUF4976)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      126157566..126234025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM89.1 GenPept UniProtKB/Swiss-Prot:Q8BM89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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