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    Fundc2b FUN14 domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 73297, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fundc2bprovided by MGI
    Official Full Name
    FUN14 domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:1920547
    See related
    Ensembl:ENSMUSG00000074619 AllianceGenome:MGI:1920547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700034I23Rik
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in autophagy of mitochondrion and intracellular triglyceride homeostasis. Located in mitochondrion. Orthologous to human FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Fundc2b in Genome Data Viewer
    Location:
    3 B; 3 19.58 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40854631..40856936, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40900196..40902501, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2011 Neighboring gene FUN14 domain containing 2 pseudogene Neighboring gene RIKEN cDNA 6430590A07 gene Neighboring gene abhydrolase domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7910 Neighboring gene STARR-seq mESC enhancer starr_07475 Neighboring gene La ribonucleoprotein 1B Neighboring gene predicted gene, 22043 Neighboring gene predicted gene 42437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143484

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1700034I23Rik
    Names
    FUN14 domain containing 2 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028494.3 → NP_082770.1  1700034I23Rik

      Status: VALIDATED

      Source sequence(s)
      AC160757
      UniProtKB/TrEMBL
      Q8C5W7, Q9D9Q3
      Related
      ENSMUSP00000141045.2, ENSMUST00000099123.5
      Conserved Domains (1) summary
      pfam04930
      Location:82 → 168
      FUN14; FUN14 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      40854631..40856936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045380.1: Suppressed sequence

      Description
      NR_045380.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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