Mcub mitochondrial calcium uniporter dominant negative beta subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcubprovided by MGI
Official Full Name: mitochondrial calcium uniporter dominant negative beta subunitprovided by MGI
Primary source: MGI:MGI:1914065
See related: Ensembl:ENSMUSG00000027994 AllianceGenome:MGI:1914065
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc109b; 9030408N13Rik
Summary: Enables calcium channel inhibitor activity. Involved in several processes, including mitochondrial calcium ion transmembrane transport; negative regulation of calcium import into the mitochondrion; and positive regulation of skeletal muscle satellite cell differentiation. Located in membrane and mitochondrion. Part of calcium channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 4.1), bladder adult (RPKM 3.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 59.56 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (129708609..129763850, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (129914960..129970211, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.
Title: MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.
Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis.
Title: Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis.
MCUb Induction Protects the Heart From Postischemic Remodeling.
Title: MCUb Induction Protects the Heart From Postischemic Remodeling.
MCUB-dependent changes in mitochondrial calcium uniporter stoichiometry are a prominent regulatory mechanism to modulate mitochondrial Ca(2+) uptake and cardiac myocyte cellular physiology.
Title: MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
Functional characterization of the MCUb protein; shows that it inhibits mitochondrial calcium uptake
Title: The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
NOT enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium import into the mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle satellite cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium uniporter regulatory subunit MCUb, mitochondrial

Names: coiled-coil domain containing 109B; coiled-coil domain-containing protein 109B; mitochondrial calcium uniporter regulatory subunit MCUb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293644.2 → NP_001280573.2 calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC118620

Consensus CDS

CCDS80021.1

UniProtKB/TrEMBL

D6RIL8

Related

ENSMUSP00000118170.3, ENSMUST00000153506.8
NM_025779.4 → NP_080055.3 calcium uniporter regulatory subunit MCUb, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

AC118620

Consensus CDS

CCDS17839.1

UniProtKB/TrEMBL

A0A9S4GQC1

Related

ENSMUSP00000029624.10, ENSMUST00000029624.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

129708609..129763850 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240197.4 → XP_011238499.1 calcium uniporter regulatory subunit MCUb, mitochondrial isoform X5
XM_006501900.3 → XP_006501963.1 calcium uniporter regulatory subunit MCUb, mitochondrial isoform X2

UniProtKB/Swiss-Prot

Q3U4A9, Q810S1, Q9CSE7, Q9D345

Conserved Domains (1) summary

pfam04678
Location:112 → 279

MCU; Mitochondrial calcium uniporter
XM_006501901.5 → XP_006501964.1 calcium uniporter regulatory subunit MCUb, mitochondrial isoform X3

UniProtKB/Swiss-Prot

Q3U4A9, Q810S1, Q9CSE7, Q9D345

Conserved Domains (1) summary

pfam04678
Location:72 → 274

MCU; Mitochondrial calcium uniporter
XM_036163230.1 → XP_036019123.1 calcium uniporter regulatory subunit MCUb, mitochondrial isoform X4

Conserved Domains (1) summary

pfam04678
Location:17 → 217

MCU; Mitochondrial calcium uniporter
XM_036163229.1 → XP_036019122.1 calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q3U4A9, Q810S1, Q9CSE7, Q9D345

Conserved Domains (1) summary

pfam04678
Location:102 → 304

MCU; Mitochondrial calcium uniporter