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    Serinc2 serine incorporator 2 [ Mus musculus (house mouse) ]

    Gene ID: 230779, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serinc2provided by MGI
    Official Full Name
    serine incorporator 2provided by MGI
    Primary source
    MGI:MGI:1919132
    See related
    Ensembl:ENSMUSG00000023232 AllianceGenome:MGI:1919132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TDE2; Tde2l; FKSG84; 2310004K20Rik
    Summary
    Predicted to be involved in phosphatidylserine metabolic process. Predicted to be active in membrane. Orthologous to human SERINC2 (serine incorporator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 101.5), colon adult (RPKM 80.2) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Serinc2 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130147289..130172993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130253495..130279218, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine decarboxylase 1 Neighboring gene predicted gene, 46724 Neighboring gene predicted gene, 34957 Neighboring gene STARR-seq mESC enhancer starr_11521 Neighboring gene fatty acid binding protein 3, muscle and heart Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in phosphatidylserine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253386.1NP_001240315.1  serine incorporator 2 isoform 2

      See identical proteins and their annotated locations for NP_001240315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK075863, AK158914, BE956082
      Consensus CDS
      CCDS57301.1
      UniProtKB/TrEMBL
      B2KFY0
      Related
      ENSMUSP00000112535.2, ENSMUST00000122374.8
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    2. NM_001356465.1NP_001343394.1  serine incorporator 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK075863, AK158914, AL606925, BE956082
      Consensus CDS
      CCDS57301.1
      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    3. NM_172702.3NP_766290.2  serine incorporator 2 isoform 1

      See identical proteins and their annotated locations for NP_766290.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA986627, BE956082, BG077215, BU511121, CB055666
      Consensus CDS
      CCDS51310.1
      UniProtKB/Swiss-Prot
      Q8K0E7
      UniProtKB/TrEMBL
      Q8C6D8
      Related
      ENSMUSP00000101618.2, ENSMUST00000105996.8
      Conserved Domains (1) summary
      pfam03348
      Location:17448
      Serinc; Serine incorporator (Serinc)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130147289..130172993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503063.3XP_006503126.1  serine incorporator 2 isoform X1

      See identical proteins and their annotated locations for XP_006503126.1

      UniProtKB/TrEMBL
      E9Q7Q6, Q8C6D8
      Related
      ENSMUSP00000113044.3, ENSMUST00000120126.9
      Conserved Domains (1) summary
      pfam03348
      Location:25457
      Serinc; Serine incorporator (Serinc)
    2. XM_036164063.1XP_036019956.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    3. XM_006503064.5XP_006503127.1  serine incorporator 2 isoform X2

      See identical proteins and their annotated locations for XP_006503127.1

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    4. XM_030253463.2XP_030109323.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    5. XM_030253461.2XP_030109321.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    6. XM_030253462.2XP_030109322.1  serine incorporator 2 isoform X2

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)
    7. XM_006503065.5XP_006503128.1  serine incorporator 2 isoform X2

      See identical proteins and their annotated locations for XP_006503128.1

      UniProtKB/TrEMBL
      B2KFY0
      Conserved Domains (1) summary
      pfam03348
      Location:1393
      Serinc; Serine incorporator (Serinc)