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    Gtf2h3 general transcription factor IIH, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 209357, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gtf2h3provided by MGI
    Official Full Name
    general transcription factor IIH, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:1277143
    See related
    Ensembl:ENSMUSG00000029387 AllianceGenome:MGI:1277143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BTF2; 34kDa; TFIIH; BTF2 p34; C730029A10; D5Ertd679e; 5033417D07Rik
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in nucleotide-excision repair and transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of core TFIIH complex portion of holo TFIIH complex; transcription factor TFIID complex; and transcription preinitiation complex. Is expressed in several structures, including blastocyst; genitourinary system; and submandibular gland primordium. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.8), limb E14.5 (RPKM 12.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gtf2h3 in Genome Data Viewer
    Location:
    5 F; 5 63.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124717211..124735743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124579148..124597680)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene DEAD box helicase 55 Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene eukaryotic translation initiation factor 2B, subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene tectonic family member 2 Neighboring gene STARR-seq mESC enhancer starr_14344 Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of core TFIIH complex portion of holo TFIIH complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor IIH subunit 3
    Names
    BTF2-p34
    TFIIH basal transcription factor complex p34 subunit
    basic transcription factor 2 34 kDa subunit
    general transcription factor IIH, polypeptide 3, 34kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181410.3NP_852075.1  general transcription factor IIH subunit 3

      See identical proteins and their annotated locations for NP_852075.1

      Status: VALIDATED

      Source sequence(s)
      AK050227, AK133941, BB637936
      Consensus CDS
      CCDS19680.1
      UniProtKB/Swiss-Prot
      Q8VD76
      UniProtKB/TrEMBL
      Q3UZB8
      Related
      ENSMUSP00000031333.4, ENSMUST00000031333.4
      Conserved Domains (1) summary
      TIGR00627
      Location:7290
      tfb4; transcription factor tfb4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124717211..124735743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)