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    Ugdh UDP-glucose dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 22235, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ugdhprovided by MGI
    Official Full Name
    UDP-glucose dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1306785
    See related
    Ensembl:ENSMUSG00000029201 AllianceGenome:MGI:1306785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Udpgdh
    Summary
    Enables UDP-glucose 6-dehydrogenase activity. Involved in UDP-glucuronate biosynthetic process; gastrulation with mouth forming second; and proteoglycan biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 86.7), limb E14.5 (RPKM 30.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Ugdh in Genome Data Viewer
    Location:
    5 C3.1; 5 33.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65570550..65593185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65413207..65435842, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3577 Neighboring gene ribosomal protein L9 Neighboring gene lipoic acid synthetase Neighboring gene VISTA enhancer mm1569 Neighboring gene STARR-seq mESC enhancer starr_13263 Neighboring gene STARR-positive B cell enhancer ABC_E4757 Neighboring gene small integral membrane protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E4758 Neighboring gene STARR-seq mESC enhancer starr_13264 Neighboring gene STARR-positive B cell enhancer ABC_E4759 Neighboring gene STARR-positive B cell enhancer ABC_E8059 Neighboring gene STARR-positive B cell enhancer ABC_E11290 Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables UDP-glucose 6-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables UDP-glucose 6-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UDP-glucuronate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in UDP-glucuronate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in UDP-glucuronate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein hexamerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    UDP-glucose 6-dehydrogenase
    Names
    UDP-Glc dehydrogenase
    UDP-GlcDH
    NP_033492.1
    XP_006503925.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009466.2NP_033492.1  UDP-glucose 6-dehydrogenase

      See identical proteins and their annotated locations for NP_033492.1

      Status: PROVISIONAL

      Source sequence(s)
      BC006749
      Consensus CDS
      CCDS19308.1
      UniProtKB/Swiss-Prot
      O70475
      UniProtKB/TrEMBL
      Q3TJ71, Q3TJE8, Q3TS38, Q3UIZ1
      Related
      ENSMUSP00000031103.8, ENSMUST00000031103.14
      Conserved Domains (1) summary
      PLN02353
      Location:4464
      PLN02353; probable UDP-glucose 6-dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65570550..65593185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503862.4XP_006503925.1  UDP-glucose 6-dehydrogenase isoform X1

      See identical proteins and their annotated locations for XP_006503925.1

      UniProtKB/Swiss-Prot
      O70475
      UniProtKB/TrEMBL
      Q3TJ71, Q3TJE8, Q3TS38, Q3UIZ1
      Conserved Domains (1) summary
      PLN02353
      Location:4464
      PLN02353; probable UDP-glucose 6-dehydrogenase