Muc2 mucin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc2provided by MGI
Official Full Name: mucin 2provided by MGI
Primary source: MGI:MGI:1339364
See related: Ensembl:ENSMUSG00000025515 AllianceGenome:MGI:1339364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MCM; wnn; 2010015E03Rik
Summary: An extracellular matrix structural constituent. Involved in host-mediated regulation of intestinal microbiota composition; maintenance of gastrointestinal epithelium; and mucus secretion. Acts upstream of or within several processes, including glandular epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is active in mucus layer. Is expressed in hindgut epithelium and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 1294.7), large intestine adult (RPKM 306.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.1 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141276583..141308428)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141690340..141754691)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Title: REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection.
Title: Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection.
IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing.
Title: IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing.
Role of Mucin 2 Glycoprotein and L-Fucose in Interaction of Immunity and Microbiome within the Experimental Model of Inflammatory Bowel Disease.
Title: Role of Mucin 2 Glycoprotein and L-Fucose in Interaction of Immunity and Microbiome within the Experimental Model of Inflammatory Bowel Disease.
Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury.
Title: Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury.
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress.
Title: Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress.
DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
Title: DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2(-/-) Mice.
Title: Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2(-/-) Mice.
Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice.
Title: Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice.
Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice.
Title: Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6) 1 citation
Endonuclease-mediated (7) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Muc2 (e-PCR), detects polymorphism
- UniSTS:530706

Muc2 (e-PCR), detects polymorphism
- UniSTS:527002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cupric ion binding	ISO Inferred from Sequence Orthology more info
enables cupric ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of copper ion	ISO Inferred from Sequence Orthology more info
involved_in detoxification of copper ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glandular epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in host-mediated regulation of intestinal microbiota composition	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of gastrointestinal epithelium	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in inner mucus layer	IDA Inferred from Direct Assay more info	PubMed
is_active_in mucus layer	IDA Inferred from Direct Assay more info	PubMed
located_in mucus layer	ISO Inferred from Sequence Orthology more info
located_in outer mucus layer	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mucin-2

Names: colonic mucin; secreted gel-forming mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023566.4 → NP_076055.4 mucin-2 precursor

Status: VALIDATED

Source sequence(s)

LXEJ02004842

UniProtKB/Swiss-Prot

A0A087WSG8, Q0P637, Q80Z17, Q80Z19, Q8K0Q1, Q9CVG8, Q9Z2U5

Related

ENSMUSP00000141040.3, ENSMUST00000185406.8

Conserved Domains (9) summary

smart00041
Location:4474 → 4553

CT; C-terminal cystine knot-like domain (CTCK)

smart00214
Location:4322 → 4386

VWC; von Willebrand factor (vWF) type C domain

smart00216
Location:848 → 1006

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:580 → 649

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:389 → 543

VWD; von Willebrand factor type D domain

pfam08742
Location:4089 → 4151

C8; C8 domain

pfam13330
Location:1300 → 1382

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

pfam17061
Location:3553 → 3644

PARM

cd19941
Location:293 → 349

TIL; trypsin inhibitor-like cysteine rich domain