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    Rfpl4 ret finger protein-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 192658, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rfpl4provided by MGI
    Official Full Name
    ret finger protein-like 4provided by MGI
    Primary source
    MGI:MGI:2149590
    See related
    Ensembl:ENSMUSG00000035191 AllianceGenome:MGI:2149590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfpl4a; D7Ertd486e
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Located in cytoplasm and female germ cell nucleus. Is expressed in bladder; central nervous system; and ureter. Orthologous to several human genes including RFPL4A (ret finger protein like 4A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward ovary adult (RPKM 1.2) See more
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    Genomic context

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    See Rfpl4 in Genome Data Viewer
    Location:
    7 A1; 7 2.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5112786..5119910, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5109787..5116911, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3697 Neighboring gene STARR-positive B cell enhancer ABC_E9020 Neighboring gene STARR-positive B cell enhancer ABC_E4891 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene epsin 1 Neighboring gene STARR-positive B cell enhancer ABC_E4892 Neighboring gene RAS-like, family 2, locus 9 Neighboring gene predicted gene, 47692

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. Rajkovic A, et al. Mech Dev, 2002 Mar. PMID 11850190
    2. RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. Suzumori N, et al. Proc Natl Acad Sci U S A, 2003 Jan 21. PMID 12525704, Free PMC Article
    3. ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. Kato Y, et al. EMBO Rep, 2019 Dec 5. PMID 31657143, Free PMC Article
    4. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Rajkovic A, et al. Science, 2004 Aug 20. PMID 15326356
    5. Maternal microRNAs are essential for mouse zygotic development. Tang F, et al. Genes Dev, 2007 Mar 15. PMID 17369397, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
      Title: The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
    2. RFPL4 functions as an E3 ubiquitin protein ligase to regulate protein degradation and meiosis in mouse oocytes.
      Title: RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ret finger protein-like 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145013.1 → NP_001138485.1  ret finger protein-like 4A

      See identical proteins and their annotated locations for NP_001138485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136022, AK139569, BC069834
      Consensus CDS
      CCDS20759.1
      UniProtKB/Swiss-Prot
      Q6IS67, Q8VH31
      UniProtKB/TrEMBL
      A0A140LIN5
      Related
      ENSMUSP00000136497.2, ENSMUST00000179971.8
      Conserved Domains (3) summary
      pfam11002
      Location:54 → 95
      RDM; RFPL defining motif (RDM)
      cd15821
      Location:94 → 272
      SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
      cl17238
      Location:11 → 52
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_138954.3 → NP_620404.1  ret finger protein-like 4A

      See identical proteins and their annotated locations for NP_620404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136022, AK139569, AY070253
      Consensus CDS
      CCDS20759.1
      UniProtKB/Swiss-Prot
      Q6IS67, Q8VH31
      UniProtKB/TrEMBL
      A0A140LIN5
      Related
      ENSMUSP00000039519.8, ENSMUST00000045215.9
      Conserved Domains (3) summary
      pfam11002
      Location:54 → 95
      RDM; RFPL defining motif (RDM)
      cd15821
      Location:94 → 272
      SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
      cl17238
      Location:11 → 52
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      5112786..5119910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VH31.1 GenPept UniProtKB/Swiss-Prot:Q8VH31

    Gene LinkOut

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