Nsmce3 NSE3 homolog, SMC5-SMC6 complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nsmce3provided by MGI
Official Full Name: NSE3 homolog, SMC5-SMC6 complex componentprovided by MGI
Primary source: MGI:MGI:1913897
See related: Ensembl:ENSMUSG00000070520 AllianceGenome:MGI:1913897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HCA4; Ndnl2; Mageg1; mage-g1; 5730494G16Rik
Summary: Predicted to enable protein dimerization activity. Acts upstream of or within regulation of DNA-templated transcription. Predicted to be located in chromosome, telomeric region and cytoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; future brain; genitourinary system; and musculature. Orthologous to human NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 C; 7 34.77 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (64521430..64522788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (64871682..64873040, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAGE-G1 interacted with fascin 1 or vimentin in P19 cells after a 6-day retinoic acid-induced neuronal differentiation.
Title: Identification of Novel MAGE-G1-Interacting Partners in Retinoic Acid-Induced P19 Neuronal Differentiation Using SILAC-Based Proteomics.
necdin and MAGE-G1 target both E2F1 and p75 to regulate cell viability during brain development.
Title: Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
gene expression, imprinting, and chromosome mapping of NDNL2 [NDNL2]
Title: A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC64493P1 (e-PCR)
- UniSTS:273415

PMC64493P2 (e-PCR)
- UniSTS:273416

BB044375 (e-PCR)
- UniSTS:185714

AI642138 (e-PCR)
- UniSTS:179581

NoName (e-PCR)
- UniSTS:235679

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroxyurea	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	ISO Inferred from Sequence Orthology more info
part_of Smc5-Smc6 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: non-structural maintenance of chromosomes element 3 homolog

Names: MAGE-G1 antigen; melanoma antigen, family G, 1; melanoma-associated antigen G1; necdin-like 2; necdin-like protein 2; non-SMC element 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.