Tjp1 tight junction protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tjp1provided by MGI
Official Full Name: tight junction protein 1provided by MGI
Primary source: MGI:MGI:98759
See related: Ensembl:ENSMUSG00000030516 AllianceGenome:MGI:98759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZO1
Summary: Enables connexin binding activity and protein domain specific binding activity. Involved in several processes, including ameloblast differentiation; negative regulation of stress fiber assembly; and positive regulation of sprouting angiogenesis. Acts upstream of or within blastocyst formation and sensory perception of sound. Located in several cellular components, including apicolateral plasma membrane; bicellular tight junction; and intercellular canaliculus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 23.6), bladder adult (RPKM 20.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 C; 7 35.02 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (64945913..65177629, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (65296165..65527850, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Experimental Corneal Neovascularization by the Tight Junction Protein ZO-1.
Title: Inhibition of Experimental Corneal Neovascularization by the Tight Junction Protein ZO-1.
ZO-1 and IL-1RAP Phosphorylation: Potential Role in Mediated Brain-Gut Axis Dysregulation in Irritable Bowel Syndrome-like Stressed Mice.
Title: ZO-1 and IL-1RAP Phosphorylation: Potential Role in Mediated Brain-Gut Axis Dysregulation in Irritable Bowel Syndrome-like Stressed Mice.
Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
Title: Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice.
Title: Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice.
Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants.
Title: Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants.
Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway.
Title: Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway.
[Effect of Connexin on Cochlear Blood-Labyrinth Barrier in a Mouse Model of Endolymphatic Hydrops].
Title: [Effect of Connexin on Cochlear Blood-Labyrinth Barrier in a Mouse Model of Endolymphatic Hydrops].
Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst.
Title: Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst.
The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
Title: The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice.
Title: Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tjp1 (e-PCR), detects polymorphism
- UniSTS:495894

TJP1 (e-PCR)
- UniSTS:479948

Tjp1 (e-PCR), detects polymorphism
- UniSTS:527578

TJP1 (e-PCR)
- UniSTS:144631

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144631

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144632

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144633

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144634

Tjp1 (e-PCR), detects polymorphism
- UniSTS:144635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables connexin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in adherens junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in ameloblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to bicellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to magnetism	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IEA Inferred from Electronic Annotation more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical junction complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: tight junction protein ZO-1

Names: zona occludens protein 1; zonula occludens protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163574.2 → NP_001157046.1 tight junction protein ZO-1 isoform 2

See identical proteins and their annotated locations for NP_001157046.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon in the middle region but has an additional in-frame segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AC122222, AC131741

Consensus CDS

CCDS52266.1

UniProtKB/TrEMBL

B9EHJ3

Related

ENSMUSP00000032729.7, ENSMUST00000032729.8

Conserved Domains (7) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1142 → 1501

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1553 → 1650

ZU5; ZU5 domain
NM_001417366.1 → NP_001404295.1 tight junction protein ZO-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122222, AC131741
NM_001417367.1 → NP_001404296.1 tight junction protein ZO-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC122222, AC131741
NM_001417368.1 → NP_001404297.1 tight junction protein ZO-1 isoform 5

Status: VALIDATED

Source sequence(s)

AC122222, AC131741
NM_001417369.1 → NP_001404298.1 tight junction protein ZO-1 isoform 6

Status: VALIDATED

Source sequence(s)

AC131741
NM_001417370.1 → NP_001404299.1 tight junction protein ZO-1 isoform 7

Status: VALIDATED

Source sequence(s)

AC131741
NM_001417371.1 → NP_001404300.1 tight junction protein ZO-1 isoform 8

Status: VALIDATED

Source sequence(s)

AC131741
NM_001417372.1 → NP_001404301.1 tight junction protein ZO-1 isoform 9

Status: VALIDATED

Source sequence(s)

AC131741
NM_001417373.1 → NP_001404302.1 tight junction protein ZO-1 isoform 10

Status: VALIDATED

Source sequence(s)

AC122222, AC122809
NM_001417374.1 → NP_001404303.1 tight junction protein ZO-1 isoform 11

Status: VALIDATED

Source sequence(s)

AC122222
NM_009386.3 → NP_033412.2 tight junction protein ZO-1 isoform 1

See identical proteins and their annotated locations for NP_033412.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC122222, AC131741

Consensus CDS

CCDS21338.1

UniProtKB/Swiss-Prot

E9QK00, P39447

Related

ENSMUSP00000099652.4, ENSMUST00000102592.10

Conserved Domains (6) summary

smart00218
Location:1629 → 1735

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

64945913..65177629 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540780.5 → XP_006540843.1 tight junction protein ZO-1 isoform X3

Conserved Domains (7) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1688

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1725 → 1824

ZU5; ZU5 domain
XM_006540778.5 → XP_006540841.1 tight junction protein ZO-1 isoform X1

Conserved Domains (8) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1705

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1227 → 1403

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1742 → 1841

ZU5; ZU5 domain
XM_006540785.5 → XP_006540848.1 tight junction protein ZO-1 isoform X9

Conserved Domains (8) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1235 → 1594

PHA03247; large tegument protein UL36; Provisional

PRK03427
Location:1163 → 1274

PRK03427; cell division protein ZipA; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1645 → 1744

ZU5; ZU5 domain
XM_006540783.5 → XP_006540846.1 tight junction protein ZO-1 isoform X7

Conserved Domains (8) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1168 → 1655

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1147 → 1323

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1662 → 1761

ZU5; ZU5 domain
XM_030242356.2 → XP_030098216.1 tight junction protein ZO-1 isoform X10

Conserved Domains (8) summary

cd12026
Location:505 → 569

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:603 → 782

GuKc; Guanylate kinase homologues

smart00228
Location:171 → 251

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:901 → 1600

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1122 → 1298

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:413 → 489

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1637 → 1736

ZU5; ZU5 domain
XM_036152893.1 → XP_036008786.1 tight junction protein ZO-1 isoform X14

Conserved Domains (8) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1075 → 1562

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1054 → 1230

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1569 → 1668

ZU5; ZU5 domain
XM_006540784.5 → XP_006540847.1 tight junction protein ZO-1 isoform X8

Conserved Domains (8) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:913 → 1612

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1134 → 1310

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1649 → 1748

ZU5; ZU5 domain
XM_006540786.5 → XP_006540849.1 tight junction protein ZO-1 isoform X13

Conserved Domains (8) summary

smart00218
Location:1642 → 1748

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1235 → 1594

PHA03247; large tegument protein UL36; Provisional

PRK03427
Location:1163 → 1274

PRK03427; cell division protein ZipA; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_036152892.1 → XP_036008785.1 tight junction protein ZO-1 isoform X12

Conserved Domains (8) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1235 → 1594

PHA03247; large tegument protein UL36; Provisional

PRK03427
Location:1163 → 1274

PRK03427; cell division protein ZipA; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1645 → 1734

ZU5; ZU5 domain
XM_006540782.5 → XP_006540845.1 tight junction protein ZO-1 isoform X6

Conserved Domains (7) summary

smart00218
Location:1722 → 1828

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1688

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_011250843.4 → XP_011249145.1 tight junction protein ZO-1 isoform X5

Conserved Domains (7) summary

smart00218
Location:1722 → 1835

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1688

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_006540781.5 → XP_006540844.1 tight junction protein ZO-1 isoform X4

Conserved Domains (8) summary

smart00218
Location:1739 → 1845

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1705

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1227 → 1403

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_006540779.5 → XP_006540842.1 tight junction protein ZO-1 isoform X2

Conserved Domains (8) summary

smart00218
Location:1739 → 1852

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1006 → 1705

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1227 → 1403

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)