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    Copb1 coatomer protein complex, subunit beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 70349, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Copb1provided by MGI
    Official Full Name
    coatomer protein complex, subunit beta 1provided by MGI
    Primary source
    MGI:MGI:1917599
    See related
    Ensembl:ENSMUSG00000030754 AllianceGenome:MGI:1917599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019B04Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in COPI-coated vesicle and Golgi apparatus. Is expressed in neocortex; sensory organ; and skeleton. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 44.6), limb E14.5 (RPKM 34.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Copb1 in Genome Data Viewer
    Location:
    7 F1; 7 59.31 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113814794..113853915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114215559..114254680, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene spondin 1, (f-spondin) extracellular matrix protein Neighboring gene STARR-positive B cell enhancer ABC_E6588 Neighboring gene STARR-positive B cell enhancer ABC_E8937 Neighboring gene predicted gene, 51454 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene related RAS viral (r-ras) oncogene 2 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene proteasome subunit alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene phosphodiesterase 3B, cGMP-inhibited

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus. Peterson TA, et al. Biochim Biophys Acta, 2013 Mar. PMID 23195223, Free PMC Article
    2. Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA. Bi J, et al. Proc Natl Acad Sci U S A, 2007 Aug 21. PMID 17698811, Free PMC Article
    3. cDNA sequence and mapping of the mouse Copb gene encoding the beta subunit of the COPI coatomer complex. LI W, et al. Somat Cell Mol Genet, 1999 May. PMID 11441537
    4. Novel Golgi protein, GoPro49, is a specific dental follicle marker. Takatalo MS, et al. J Dent Res, 2009 Jun. PMID 19587158
    5. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Sagiv Y, et al. EMBO J, 2000 Apr 3. PMID 10747018, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit beta
    Names
    beta-COP
    beta-coat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033370.3 → NP_203534.1  coatomer subunit beta

      See identical proteins and their annotated locations for NP_203534.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161930
      Consensus CDS
      CCDS21759.1
      UniProtKB/Swiss-Prot
      Q3T9Y4, Q3TT72, Q3U8G9, Q3UE02, Q9JIF7
      Related
      ENSMUSP00000033012.8, ENSMUST00000033012.9
      Conserved Domains (4) summary
      sd00044
      Location:137 → 161
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:18 → 550
      Adaptin_N; Adaptin N terminal region
      pfam07718
      Location:667 → 807
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:813 → 944
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      113814794..113853915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIF7.1 GenPept UniProtKB/Swiss-Prot:Q9JIF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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