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    Cdh13 cadherin 13 [ Mus musculus (house mouse) ]

    Gene ID: 12554, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdh13provided by MGI
    Official Full Name
    cadherin 13provided by MGI
    Primary source
    MGI:MGI:99551
    See related
    Ensembl:ENSMUSG00000031841 AllianceGenome:MGI:99551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdht; Tcad; 4932416G01Rik
    Summary
    This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in heart adult (RPKM 39.2), CNS E18 (RPKM 17.5) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cdh13 in Genome Data Viewer
    Location:
    8 E1; 8 65.97 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (119010150..120051668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (118140017..119324929)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39262 Neighboring gene STARR-seq mESC enhancer starr_22828 Neighboring gene STARR-seq mESC enhancer starr_22829 Neighboring gene predicted gene, 25200 Neighboring gene STARR-seq mESC enhancer starr_22830 Neighboring gene predicted gene, 51555 Neighboring gene STARR-seq mESC enhancer starr_22831 Neighboring gene STARR-seq mESC enhancer starr_22832 Neighboring gene STARR-seq mESC enhancer starr_22833 Neighboring gene STARR-seq mESC enhancer starr_22834 Neighboring gene STARR-seq mESC enhancer starr_22835 Neighboring gene predicted gene, 24035 Neighboring gene STARR-seq mESC enhancer starr_22837 Neighboring gene STARR-seq mESC enhancer starr_22838 Neighboring gene STARR-seq mESC enhancer starr_22840 Neighboring gene predicted gene, 53461 Neighboring gene STARR-seq mESC enhancer starr_22841 Neighboring gene predicted gene, 22999 Neighboring gene STARR-seq mESC enhancer starr_22842 Neighboring gene STARR-seq mESC enhancer starr_22844 Neighboring gene predicted gene, 31893 Neighboring gene STARR-seq mESC enhancer starr_22846 Neighboring gene STARR-seq mESC enhancer starr_22847 Neighboring gene STARR-positive B cell enhancer ABC_E10525 Neighboring gene predicted gene 45723 Neighboring gene heat shock factor binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adiponectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in localization within membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in localization within membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in low-density lipoprotein particle mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cadherin-13
    Names
    H-cadherin
    T-cadherin
    heart cadherin
    NP_062681.2
    XP_006530691.2
    XP_036009632.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019707.5NP_062681.2  cadherin-13 preproprotein

      See identical proteins and their annotated locations for NP_062681.2

      Status: REVIEWED

      Source sequence(s)
      AI550332, AK048724, AV343697, BB075948, BM944611, CF735928, CX242668
      Consensus CDS
      CCDS52682.1
      UniProtKB/Swiss-Prot
      Q8BG11, Q9WTR5
      UniProtKB/TrEMBL
      Q8VDK4
      Related
      ENSMUSP00000113527.2, ENSMUST00000117160.2
      Conserved Domains (4) summary
      cd11304
      Location:488581
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:161243
      CA; Cadherin repeats
      pfam00028
      Location:368469
      Cadherin; Cadherin domain
      pfam08758
      Location:26112
      Cadherin_pro; Cadherin prodomain like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      119010150..120051668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153739.1XP_036009632.1  cadherin-13 isoform X2

      UniProtKB/TrEMBL
      Q8BS79
      Conserved Domains (2) summary
      smart00112
      Location:161243
      CA; Cadherin repeats
      pfam08758
      Location:26112
      Cadherin_pro; Cadherin prodomain like
    2. XM_006530628.4XP_006530691.2  cadherin-13 isoform X1

      UniProtKB/TrEMBL
      Q8VDK4
      Conserved Domains (4) summary
      cd11304
      Location:475568
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:148230
      CA; Cadherin repeats
      cl29226
      Location:577667
      Cadherin; Cadherin domain
      pfam08758
      Location:1399
      Cadherin_pro; Cadherin prodomain like