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    Hsbp1 heat shock factor binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 68196, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hsbp1provided by MGI
    Official Full Name
    heat shock factor binding protein 1provided by MGI
    Primary source
    MGI:MGI:1915446
    See related
    Ensembl:ENSMUSG00000031839 AllianceGenome:MGI:1915446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsp25; 0610007A03Rik
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within endodermal cell differentiation. Predicted to be located in axon cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including early embryo and ganglia. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 226.9), CNS E18 (RPKM 192.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Hsbp1 in Genome Data Viewer
    Location:
    8 E1; 8 67.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120071277..120075668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119344538..119348929)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cadherin 13 Neighboring gene STARR-seq mESC enhancer starr_22840 Neighboring gene STARR-seq mESC enhancer starr_22841 Neighboring gene predicted gene, 22999 Neighboring gene STARR-seq mESC enhancer starr_22842 Neighboring gene STARR-seq mESC enhancer starr_22844 Neighboring gene predicted gene, 31893 Neighboring gene STARR-seq mESC enhancer starr_22846 Neighboring gene STARR-seq mESC enhancer starr_22847 Neighboring gene STARR-positive B cell enhancer ABC_E10525 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene predicted gene 45723 Neighboring gene predicted gene, 32006 Neighboring gene malonyl-CoA decarboxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular heat acclimation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heat shock factor-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024219.1NP_077181.1  heat shock factor-binding protein 1

      See identical proteins and their annotated locations for NP_077181.1

      Status: VALIDATED

      Source sequence(s)
      BC002153
      Consensus CDS
      CCDS40492.1
      UniProtKB/Swiss-Prot
      Q3UKN1, Q9CQZ1
      Related
      ENSMUSP00000034300.7, ENSMUST00000034300.8
      Conserved Domains (1) summary
      pfam06825
      Location:1060
      HSBP1; Heat shock factor binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120071277..120075668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)