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    Necab2 N-terminal EF-hand calcium binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 117148, updated on 9-Dec-2024

    Summary

    Official Symbol
    Necab2provided by MGI
    Official Full Name
    N-terminal EF-hand calcium binding protein 2provided by MGI
    Primary source
    MGI:MGI:2152211
    See related
    Ensembl:ENSMUSG00000031837 AllianceGenome:MGI:2152211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Efcbp2
    Summary
    Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in brain; embryo ectoderm; eye; nasal pit; and trigeminal ganglion. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 6.6), CNS E18 (RPKM 5.5) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Necab2 in Genome Data Viewer
    Location:
    8 E1; 8 67.73 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120173431..120199379)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119446719..119472640)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene malonyl-CoA decarboxylase Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene predicted gene, 53462 Neighboring gene STARR-seq mESC enhancer starr_22850 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene STARR-seq mESC enhancer starr_22853 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122082621-122082922

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141287, MGC141288

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A2A adenosine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables A2A adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 metabotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-terminal EF-hand calcium-binding protein 2
    Names
    EF hand calcium binding protein 2
    neuronal calcium binding 2
    neuronal calcium-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054095.2NP_473436.1  N-terminal EF-hand calcium-binding protein 2

      See identical proteins and their annotated locations for NP_473436.1

      Status: PROVISIONAL

      Source sequence(s)
      AC166781
      Consensus CDS
      CCDS22705.1
      UniProtKB/Swiss-Prot
      Q1LZI4, Q8C492, Q91ZP9
      UniProtKB/TrEMBL
      Q3B7X9
      Related
      ENSMUSP00000095966.4, ENSMUST00000098363.10
      Conserved Domains (3) summary
      cd00051
      Location:68130
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam03992
      Location:291361
      ABM; Antibiotic biosynthesis monooxygenase
      pfam13499
      Location:68126
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120173431..120199379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153728.1XP_036009621.1  N-terminal EF-hand calcium-binding protein 2 isoform X2

      Conserved Domains (1) summary
      pfam03992
      Location:162232
      ABM; Antibiotic biosynthesis monooxygenase
    2. XM_017312526.3XP_017168015.1  N-terminal EF-hand calcium-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q91ZP9
      Conserved Domains (1) summary
      pfam03992
      Location:162232
      ABM; Antibiotic biosynthesis monooxygenase
    3. XM_036153727.1XP_036009620.1  N-terminal EF-hand calcium-binding protein 2 isoform X1

      Conserved Domains (1) summary
      pfam03992
      Location:179249
      ABM; Antibiotic biosynthesis monooxygenase