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    Adad2 adenosine deaminase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 75773, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adad2provided by MGI
    Official Full Name
    adenosine deaminase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1923023
    See related
    Ensembl:ENSMUSG00000024266 AllianceGenome:MGI:1923023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930403J07Rik
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in spermatid development. Located in cytoplasm and nucleus. Is expressed in central nervous system; sensory organ; and testis. Orthologous to human ADAD2 (adenosine deaminase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 24.1) and duodenum adult (RPKM 1.4) See more
    Orthologs
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    Genomic context

    See Adad2 in Genome Data Viewer
    Location:
    8 E1; 8 68.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120339449..120343665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119612710..119616926)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene potassium voltage-gated channel, subfamily G, member 4 Neighboring gene predicted gene, 46055 Neighboring gene predicted gene, 46054

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenosine deaminase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029428.2NP_083704.1  adenosine deaminase domain-containing protein 2

      See identical proteins and their annotated locations for NP_083704.1

      Status: VALIDATED

      Source sequence(s)
      AC104882
      Consensus CDS
      CCDS52683.1
      UniProtKB/Swiss-Prot
      B2RQL4, Q9D5P4
      Related
      ENSMUSP00000095964.3, ENSMUST00000098361.4
      Conserved Domains (2) summary
      cd00048
      Location:101157
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02137
      Location:239554
      A_deamin; Adenosine-deaminase (editase) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120339449..120343665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531467.2XP_006531530.1  adenosine deaminase domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      cl00054
      Location:90157
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl02661
      Location:239272
      A_deamin; Adenosine-deaminase (editase) domain
    2. XM_006531464.2XP_006531527.1  adenosine deaminase domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      cl00054
      Location:90157
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl02661
      Location:239488
      A_deamin; Adenosine-deaminase (editase) domain