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    Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 69047, updated on 27-Nov-2024

    Summary

    Official Symbol
    Atp2c2provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, type 2C, member 2provided by MGI
    Primary source
    MGI:MGI:1916297
    See related
    Ensembl:ENSMUSG00000034112 AllianceGenome:MGI:1916297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spca2; mKIAA0703; 1810010G06Rik
    Summary
    Predicted to enable P-type calcium transporter activity and P-type manganese transporter activity. Acts upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Located in several cellular components, including cytoplasmic side of plasma membrane; perinuclear region of cytoplasm; and trans-Golgi network membrane. Orthologous to human ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 32.1), large intestine adult (RPKM 4.2) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp2c2 in Genome Data Viewer
    Location:
    8 E1; 8 68.21 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120426748..120484457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119700009..119757718)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32352 Neighboring gene WAP four-disulfide core domain 1 Neighboring gene predicted gene, 53463 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122241776-122242076 Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene STARR-positive B cell enhancer ABC_E113 Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122361795-122361952 Neighboring gene STARR-positive B cell enhancer ABC_E2880

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Clone Names

    • KIAA0703

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type calcium transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables P-type manganese transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type manganese transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcium-transporting ATPase type 2C member 2
    Names
    ATPase 2C2
    Ca(2+)/Mn(2+)-ATPase 2C2
    Secretory pathway Ca(2+)-ATPase 2
    secretory pathway Ca(2+)-transporting ATPase type 2
    secretory pathway Ca2+-ATPase
    NP_081198.1
    XP_006531407.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026922.1NP_081198.1  calcium-transporting ATPase type 2C member 2

      See identical proteins and their annotated locations for NP_081198.1

      Status: VALIDATED

      Source sequence(s)
      AC104882, AC161435
      Consensus CDS
      CCDS52684.1
      UniProtKB/Swiss-Prot
      A7L9Z8, Q5DU19
      Related
      ENSMUSP00000092794.4, ENSMUST00000095171.5
      Conserved Domains (6) summary
      TIGR01522
      Location:54929
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:584707
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:135366
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:754927
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:61123
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:439521
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120426748..120484457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531344.2XP_006531407.1  calcium-transporting ATPase type 2C member 2 isoform X1

      UniProtKB/TrEMBL
      Q80XS9
      Conserved Domains (1) summary
      cl21460
      Location:1747
      HAD_like; Haloacid Dehalogenase-like Hydrolases