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    Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 60507, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Qtrt1provided by MGI
    Official Full Name
    queuine tRNA-ribosyltransferase catalytic subunit 1provided by MGI
    Primary source
    MGI:MGI:1931441
    See related
    Ensembl:ENSMUSG00000002825 AllianceGenome:MGI:1931441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tgt; 2610028E17Rik
    Summary
    Enables tRNA-guanosine(34) queuine transglycosylase activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane and nucleus. Part of protein-containing complex. Colocalizes with mitochondrion. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and urinary system. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.5), limb E14.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Qtrt1 in Genome Data Viewer
    Location:
    9 A3; 9 7.79 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21323096..21331575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21411801..21420279)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E2284 Neighboring gene predicted gene, 16853 Neighboring gene STARR-positive B cell enhancer ABC_E134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21240723-21240906 Neighboring gene dynamin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21254333-21254586 Neighboring gene predicted gene, 46104 Neighboring gene predicted gene, 57796 Neighboring gene microRNA 199a-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed. Cirzi C, et al. EMBO J, 2023 Oct 4. PMID 37609797, Free PMC Article
    2. Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation. Rakovich T, et al. J Biol Chem, 2011 Jun 3. PMID 21487017, Free PMC Article
    3. Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel Disease. Zhang J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36801450, Free PMC Article
    4. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Sebastiani M, et al. ACS Chem Biol, 2022 Aug 19. PMID 35815944
    5. In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis. Varghese S, et al. Nucleic Acids Res, 2017 Feb 28. PMID 28204548, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
      Title: Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-guanosine(34) queuine transglycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA-guanine transglycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA-guanine transglycosylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    queuine tRNA-ribosyltransferase catalytic subunit 1
    Names
    guanine insertion enzyme
    queuine tRNA-ribosyltransferase 1
    tRNA-guanine transglycosylase
    NP_068688.2
    XP_006510587.1
    XP_011240885.1
    XP_036011059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021888.2 → NP_068688.2  queuine tRNA-ribosyltransferase catalytic subunit 1

      See identical proteins and their annotated locations for NP_068688.2

      Status: VALIDATED

      Source sequence(s)
      AB034632, AI842405, BY291101
      Consensus CDS
      CCDS52735.1
      UniProtKB/Swiss-Prot
      Q80VS3, Q9JMA2
      Related
      ENSMUSP00000002902.7, ENSMUST00000002902.8
      Conserved Domains (1) summary
      pfam01702
      Location:26 → 381
      TGT; Queuine tRNA-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21323096..21331575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510524.5 → XP_006510587.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X2

      Conserved Domains (1) summary
      pfam01702
      Location:26 → 287
      TGT; Queuine tRNA-ribosyltransferase

    2. XM_036155166.1 → XP_036011059.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X1

      Conserved Domains (1) summary
      pfam01702
      Location:1 → 286
      TGT; Queuine tRNA-ribosyltransferase

    3. XM_011242583.2 → XP_011240885.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X3

      Conserved Domains (1) summary
      pfam01702
      Location:28 → 194
      TGT; Queuine tRNA-ribosyltransferase

    RNA

    1. XR_003947961.2 RNA Sequence

    2. XR_003947960.2 RNA Sequence

    3. XR_379128.5 RNA Sequence

    4. XR_001778954.3 RNA Sequence

    5. XR_004935511.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMA2.2 GenPept UniProtKB/Swiss-Prot:Q9JMA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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