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    Cfap141 cilia and flagella associated protein 141 [ Mus musculus (house mouse) ]

    Gene ID: 73545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap141provided by MGI
    Official Full Name
    cilia and flagella associated protein 141provided by MGI
    Primary source
    MGI:MGI:1920795
    See related
    Ensembl:ENSMUSG00000118506 AllianceGenome:MGI:1920795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700094D03Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human CFAP141 (cilia and flagella associated protein 141). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.6), lung adult (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap141 in Genome Data Viewer
    Location:
    3 F1; 3 39.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89970115..89975654)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90062808..90068347)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2-like Neighboring gene microRNA 7669 Neighboring gene RIKEN cDNA 4933434E20 gene Neighboring gene STARR-seq mESC enhancer starr_08270 Neighboring gene STARR-seq mESC enhancer starr_08271 Neighboring gene microRNA 190b Neighboring gene STARR-positive B cell enhancer ABC_E3447 Neighboring gene STARR-positive B cell enhancer ABC_E7923 Neighboring gene STARR-seq mESC enhancer starr_08272 Neighboring gene tropomyosin 3, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
    2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 141
    Names
    protein CFAP141
    uncharacterized protein C1orf189 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028567.2 → NP_082843.2  cilia- and flagella-associated protein 141

      Status: VALIDATED

      Source sequence(s)
      AC163616
      Consensus CDS
      CCDS50968.2
      UniProtKB/Swiss-Prot
      Q9D9D9
      Related
      ENSMUSP00000158884.2, ENSMUST00000238911.2
      Conserved Domains (1) summary
      pfam15104
      Location:15 → 100
      DUF4558; Domain of unknown function (DUF4558)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89970115..89975654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9D9.2 GenPept UniProtKB/Swiss-Prot:Q9D9D9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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