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    Csrnp1 cysteine-serine-rich nuclear protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 215418, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Csrnp1provided by MGI
    Official Full Name
    cysteine-serine-rich nuclear protein 1provided by MGI
    Primary source
    MGI:MGI:2387989
    See related
    Ensembl:ENSMUSG00000032515 AllianceGenome:MGI:2387989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Axud1; URAX1; taip-3; CSRNP-1; 4931429D10Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including face morphogenesis; platelet-derived growth factor receptor signaling pathway; and roof of mouth development. Located in nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 18.0), testis adult (RPKM 16.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csrnp1 in Genome Data Viewer
    Location:
    9 F4; 9 71.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119800229..119813808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119971163..119984742, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119887435-119887544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119888013-119888122 Neighboring gene STARR-positive B cell enhancer ABC_E6811 Neighboring gene STARR-positive B cell enhancer ABC_E2922 Neighboring gene STARR-positive B cell enhancer ABC_E3866 Neighboring gene predicted gene, 33800 Neighboring gene STARR-seq mESC enhancer starr_25485 Neighboring gene STARR-seq mESC enhancer starr_25486 Neighboring gene STARR-positive B cell enhancer ABC_E9780 Neighboring gene xin actin-binding repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling. Ye X, et al. Exp Cell Res, 2017 Oct 15. PMID 28830684
    2. Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis. Chen WV, et al. Nat Genet, 2004 Mar. PMID 14981515
    3. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. Ze Y, et al. J Biomed Mater Res A, 2014 Feb. PMID 23533084
    4. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
    5. PDGF signaling specificity is mediated through multiple immediate early genes. Schmahl J, et al. Nat Genet, 2007 Jan. PMID 17143286

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway.
      Title: Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
    2. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs
      Title: Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine/serine-rich nuclear protein 1
    Names
    AXIN1 up-regulated 1
    TGF-beta induced apoptosis protein 3
    axin-1 up-regulated gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357560.1 → NP_001344489.1  cysteine/serine-rich nuclear protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AC124662, AK029893
      Consensus CDS
      CCDS23620.1
      UniProtKB/Swiss-Prot
      P59054, Q3USP7
      Related
      ENSMUSP00000150628.2, ENSMUST00000214058.2
      Conserved Domains (1) summary
      pfam16019
      Location:80 → 303
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. NM_001357561.1 → NP_001344490.1  cysteine/serine-rich nuclear protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC124662, AK140213
      Consensus CDS
      CCDS23620.1
      UniProtKB/Swiss-Prot
      P59054, Q3USP7
      Related
      ENSMUSP00000035101.8, ENSMUST00000035101.9
      Conserved Domains (1) summary
      pfam16019
      Location:80 → 303
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    3. NM_001357562.1 → NP_001344491.1  cysteine/serine-rich nuclear protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC117245, AC124662
      Consensus CDS
      CCDS23620.1
      UniProtKB/Swiss-Prot
      P59054, Q3USP7
      Conserved Domains (1) summary
      pfam16019
      Location:80 → 303
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. NM_153287.4 → NP_695019.1  cysteine/serine-rich nuclear protein 1

      See identical proteins and their annotated locations for NP_695019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC117245, AC124662
      Consensus CDS
      CCDS23620.1
      UniProtKB/Swiss-Prot
      P59054, Q3USP7
      Conserved Domains (1) summary
      pfam16019
      Location:80 → 303
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119800229..119813808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512040.4 → XP_006512103.1  cysteine/serine-rich nuclear protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006512103.1

      UniProtKB/Swiss-Prot
      P59054, Q3USP7
      Conserved Domains (1) summary
      pfam16019
      Location:80 → 303
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59054.1 GenPept UniProtKB/Swiss-Prot:P59054

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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