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    Bcorl1 BCL6 co-repressor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 320376, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcorl1provided by MGI
    Official Full Name
    BCL6 co-repressor-like 1provided by MGI
    Primary source
    MGI:MGI:2443910
    See related
    Ensembl:ENSMUSG00000036959 AllianceGenome:MGI:2443910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720425J07Rik; B930011H20Rik
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 2.4), CNS E11.5 (RPKM 2.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcorl1 in Genome Data Viewer
    Location:
    X A5; X 25.64 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47430235..47496945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48341358..48408068)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7688 Neighboring gene predicted gene, 39511 Neighboring gene RIKEN cDNA 9530027J09 gene Neighboring gene UTP14A small subunit processome component Neighboring gene STARR-positive B cell enhancer mm9_chrX:45637714-45638015 Neighboring gene STARR-seq mESC enhancer starr_47113 Neighboring gene STARR-seq mESC enhancer starr_47114 Neighboring gene STARR-seq mESC enhancer starr_47116 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis. Lu C, et al. J Med Genet, 2021 Jan. PMID 32376790
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCL-6 corepressor-like protein 1
    Names
    BCoR-L1
    BCoR-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178782.4 → NP_848897.3  BCL-6 corepressor-like protein 1

      See identical proteins and their annotated locations for NP_848897.3

      Status: VALIDATED

      Source sequence(s)
      AK081004, AL844594, CJ176997, CO044036
      Consensus CDS
      CCDS40961.1
      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Related
      ENSMUSP00000122000.2, ENSMUST00000136348.8
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47430235..47496945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161982.1 → XP_036017875.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006541497.4 → XP_006541560.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006541560.1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006541499.5 → XP_006541562.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006541562.1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006541498.5 → XP_006541561.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006541561.1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Related
      ENSMUSP00000039898.7, ENSMUST00000037596.13
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_030251371.2 → XP_030107231.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006541500.4 → XP_006541563.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006541563.1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_030251370.1 → XP_030107230.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AQH4, Q8BMH7, Q8BV26, Q8BW58
      UniProtKB/TrEMBL
      F8WJL9
      Conserved Domains (5) summary
      PHA03247
      Location:182 → 630
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1662 → 1775
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam05109
      Location:442 → 833
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:1494 → 1525
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1498 → 1589
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AQH4.1 GenPept UniProtKB/Swiss-Prot:A2AQH4

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