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    ZNF446 zinc finger protein 446 [ Homo sapiens (human) ]

    Gene ID: 55663, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF446provided by HGNC
    Official Full Name
    zinc finger protein 446provided by HGNC
    Primary source
    HGNC:HGNC:21036
    See related
    Ensembl:ENSG00000083838 AllianceGenome:HGNC:21036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN30; ZSCAN52; ZKSCAN20
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF446 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58476352..58489533)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61572319..61585623)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58987719..59000900)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 250 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58962695-58963021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978178-58978794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978795-58979409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15199 Neighboring gene zinc finger protein 324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15201 Neighboring gene Sharpr-MPRA regulatory region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15203 Neighboring gene uncharacterized LOC112268251 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene solute carrier family 27 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. Liu F, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936718
    2. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
    3. Network-based prediction of protein interactions. Kovács IA, et al. Nat Commun, 2019 Mar 18. PMID 30886144, Free PMC Article
    4. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. Martínez-Noël G, et al. J Mol Biol, 2018 Mar 30. PMID 29426014, Free PMC Article
    5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1.
      Title: A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ17426, FLJ20626

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 446
    Names
    zinc finger protein with KRAB and SCAN domains 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304453.1 → NP_001291382.1  zinc finger protein 446 isoform 2

      See identical proteins and their annotated locations for NP_001291382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a shorter 5' UTR and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AL833955, BQ441187, DA162028
      UniProtKB/TrEMBL
      Q8NDK2
      Conserved Domains (3) summary
      smart00431
      Location:22 → 137
      SCAN; leucine rich region
      pfam01352
      Location:209 → 237
      KRAB; KRAB box
      pfam02023
      Location:22 → 110
      SCAN; SCAN domain

    2. NM_017908.4 → NP_060378.1  zinc finger protein 446 isoform 1

      See identical proteins and their annotated locations for NP_060378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK000633, AL122108, DA162028
      Consensus CDS
      CCDS12982.1
      UniProtKB/Swiss-Prot
      Q96AF5, Q9NWS9
      UniProtKB/TrEMBL
      M0R202
      Related
      ENSP00000472802.1, ENST00000594369.6
      Conserved Domains (3) summary
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:209 → 238
      KRAB; KRAB box
      cl02605
      Location:22 → 137
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58476352..58489533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61572319..61585623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWS9.1 GenPept UniProtKB/Swiss-Prot:Q9NWS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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