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    CASC8 cancer susceptibility 8 [ Homo sapiens (human) ]

    Gene ID: 727677, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CASC8provided by HGNC
    Official Full Name
    cancer susceptibility 8provided by HGNC
    Primary source
    HGNC:HGNC:45129
    See related
    Ensembl:ENSG00000246228 MIM:617701; AllianceGenome:HGNC:45129
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CARLO1; CARLo-1; LINC00860
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See CASC8 in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127289676..127482139, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (128416883..128609574, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128301921..128494384, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CASC19-CCAT1 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27934 Neighboring gene CCAT1 intron CAGE-defined B cell enhancer Neighboring gene Sharpr-MPRA regulatory region 9947 Neighboring gene cancer susceptibility 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27936 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128264283-128264878 Neighboring gene colon cancer associated transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27938 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128295539-128296172 Neighboring gene cancer susceptibility 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128304713-128305280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27940 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128352096-128353295 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128383298-128383801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128444461-128445375 Neighboring gene POU class 5 homeobox 1B Neighboring gene colon cancer associated transcript 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19528 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128620950-128621545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27946 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658093-128658594 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658595-128659094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128672691-128673890 Neighboring gene uncharacterized LOC105375754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128681305-128681805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128717643-128718143 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene origin of replication upstream of MYC Neighboring gene cancer susceptibility 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity. Hu L, et al. Int J Environ Res Public Health, 2016 May 30. PMID 27249003, Free PMC Article
    2. A common variant associated with prostate cancer in European and African populations. Amundadottir LT, et al. Nat Genet, 2006 Jun. PMID 16682969
    3. Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population. Ma G, et al. J Gastroenterol Hepatol, 2015 Apr. PMID 25302443
    4. Long Noncoding RNA Cancer Susceptibility Candidate 8 Suppresses the Proliferation of Bladder Cancer Cells via Regulating Glycolysis. Hu R, et al. DNA Cell Biol, 2017 Sep. PMID 28759252
    5. Lack of association of CASC8 rs1447295 with colorectal cancer in Iranian population: A multicenter case-control study. Haerian MS, et al. Gene, 2017 Nov 15. PMID 28887158

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.
      Title: TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.
    2. The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
      Title: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
    3. Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus.
      Title: Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus.
    4. Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
      Title: Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
    5. Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
      Title: Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
    6. Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.
      Title: Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.
    7. association of CASC8 gene polymorphisms with the occurrence and progression of hepatocellular carcinoma
      Title: Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma.
    8. CASC8 reduced the glycolysis of bladder cancer cells via interacting with the fibroblast growth factor receptor 1.
      Title: Long Noncoding RNA Cancer Susceptibility Candidate 8 Suppresses the Proliferation of Bladder Cancer Cells via Regulating Glycolysis.
    9. Results show no association of CASC8 rs1447295 with colorectal cancer in Iranian population.
      Title: Lack of association of CASC8 rs1447295 with colorectal cancer in Iranian population: A multicenter case-control study.
    10. study showed that lncRNA CASC8 rs10505477 polymorphism was significantly related to lung cancer susceptibility and overall severe toxicity induced by platinum-based chemotherapy in lung cancers.
      Title: Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
    EBI GWAS Catalog
    Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
    EBI GWAS Catalog
    Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
    EBI GWAS Catalog
    Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • cancer susceptibility 8 (non-protein coding)
    • cancer susceptibility candidate 8 (non-protein coding)
    • long intergenic non-protein coding RNA 860

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024393.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC016883
      Related
      ENST00000502056.1

    2. NR_117100.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC016883, AC018714
      Related
      ENST00000502082.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      127289676..127482139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      128416883..128609574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials