U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF705G zinc finger protein 705G [ Homo sapiens (human) ]

    Gene ID: 100131980, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF705Gprovided by HGNC
    Official Full Name
    zinc finger protein 705Gprovided by HGNC
    Primary source
    HGNC:HGNC:37134
    See related
    Ensembl:ENSG00000215372 AllianceGenome:HGNC:37134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZNF705G in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7355517..7385558, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7020087..7114544, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7213039..7243080, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 66 member B Neighboring gene ubiquitin specific peptidase 17 like family member 4 Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26961 Neighboring gene defensin beta 108C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7251267-7252216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253130-7253706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253707-7254283 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:7259671-7260248 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7264652-7265597 Neighboring gene defensin beta 4B Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
    2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article
    3. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative zinc finger protein 705G

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164457.3 → NP_001157929.1  putative zinc finger protein 705G

      See identical proteins and their annotated locations for NP_001157929.1

      Status: VALIDATED

      Source sequence(s)
      AC130360
      Consensus CDS
      CCDS47773.1
      UniProtKB/Swiss-Prot
      A8MUZ8
      Related
      ENSP00000383020.4, ENST00000400156.4
      Conserved Domains (5) summary
      smart00349
      Location:7 → 66
      KRAB; krueppel associated box
      COG5048
      Location:92 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174 → 194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:186 → 211
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      7355517..7385558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      5523302..5609712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332218.1 → XP_054188193.1  putative zinc finger protein 705G isoform X5

    2. XM_054332227.1 → XP_054188202.1  putative zinc finger protein 705G isoform X12

    3. XM_054332222.1 → XP_054188197.1  putative zinc finger protein 705G isoform X9

    4. XM_054332223.1 → XP_054188198.1  putative zinc finger protein 705G isoform X8

    5. XM_054332214.1 → XP_054188189.1  putative zinc finger protein 705G isoform X1

    6. XM_054332217.1 → XP_054188192.1  putative zinc finger protein 705G isoform X4

    7. XM_054332216.1 → XP_054188191.1  putative zinc finger protein 705G isoform X3

    8. XM_054332228.1 → XP_054188203.1  putative zinc finger protein 705G isoform X13

    9. XM_054332224.1 → XP_054188199.1  putative zinc finger protein 705G isoform X8

    10. XM_054332215.1 → XP_054188190.1  putative zinc finger protein 705G isoform X2

    11. XM_054332225.1 → XP_054188200.1  putative zinc finger protein 705G isoform X10

    12. XM_054332221.1 → XP_054188196.1  putative zinc finger protein 705G isoform X8

    13. XM_054332220.1 → XP_054188195.1  putative zinc finger protein 705G isoform X7

    14. XM_054332229.1 → XP_054188204.1  putative zinc finger protein 705G isoform X14

    15. XM_054332226.1 → XP_054188201.1  putative zinc finger protein 705G isoform X11

    16. XM_054332219.1 → XP_054188194.1  putative zinc finger protein 705G isoform X6

    RNA

    1. XR_008485749.1 RNA Sequence

    2. XR_008485750.1 RNA Sequence

    3. XR_008485751.1 RNA Sequence

    4. XR_008485752.1 RNA Sequence

    5. XR_008485754.1 RNA Sequence

    6. XR_008485753.1 RNA Sequence

    7. XR_002959146.2 RNA Sequence

    8. XR_007069096.1 RNA Sequence

    9. XR_007069094.1 RNA Sequence

    10. XR_002959142.2 RNA Sequence

    11. XR_007069099.1 RNA Sequence

    12. XR_007069101.1 RNA Sequence

    13. XR_007069100.1 RNA Sequence

    14. XR_007069097.1 RNA Sequence

    15. XR_007069095.1 RNA Sequence

    16. XR_007069103.1 RNA Sequence

    17. XR_007069102.1 RNA Sequence

    18. XR_007069098.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187570.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      39798..68296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      7020087..7114544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359517.1 → XP_054215492.1  putative zinc finger protein 705G isoform X16

    2. XM_054359518.1 → XP_054215493.1  putative zinc finger protein 705G isoform X16

    3. XM_054359519.1 → XP_054215494.1  putative zinc finger protein 705G isoform X16

    4. XM_054359516.1 → XP_054215491.1  putative zinc finger protein 705G isoform X15

    5. XM_054359521.1 → XP_054215496.1  putative zinc finger protein 705G isoform X17

    6. XM_054359520.1 → XP_054215495.1  putative zinc finger protein 705G isoform X17

    7. XM_054359523.1 → XP_054215498.1  putative zinc finger protein 705G isoform X19

    8. XM_054359522.1 → XP_054215497.1  putative zinc finger protein 705G isoform X18

    RNA

    1. XR_008487791.1 RNA Sequence

    2. XR_008487789.1 RNA Sequence

    3. XR_008487790.1 RNA Sequence

    4. XR_007078653.1 RNA Sequence

    5. XR_007078654.1 RNA Sequence

    6. XR_008487792.1 RNA Sequence

    7. XR_008487788.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MUZ8.2 GenPept UniProtKB/Swiss-Prot:A8MUZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous