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    Ly6g6d lymphocyte antigen 6 family member G6D [ Mus musculus (house mouse) ]

    Gene ID: 114654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ly6g6dprovided by MGI
    Official Full Name
    lymphocyte antigen 6 family member G6Dprovided by MGI
    Primary source
    MGI:MGI:2148931
    See related
    Ensembl:ENSMUSG00000073413 AllianceGenome:MGI:2148931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G6d; G6f; NG25; NG32; MEGT1; g6f-ly6g6d; A930024F17Rik
    Summary
    Enables acetylcholine receptor inhibitor activity and identical protein binding activity. Acts upstream of or within acetylcholine receptor signaling pathway. Part of protein-containing complex. Colocalizes with external side of plasma membrane. Is expressed in brain; embryo; lung; and metanephros. Orthologous to human LY6G6D (lymphocyte antigen 6 family member G6D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 4.5), lung adult (RPKM 3.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ly6g6d in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35290318..35300215, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35071342..35081239, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A Neighboring gene lymphocyte antigen 6 family member G5C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. Mallya M, et al. Genomics, 2002 Jul. PMID 12079290
    2. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
    3. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. Mallya M, et al. Protein Sci, 2006 Oct. PMID 17008713, Free PMC Article
    4. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6 complex locus protein G6d
    Names
    lymphocyte antigen 6 complex, locus G6D
    megakaryocyte-enhanced gene transcript 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371027.1 → NP_001357956.1  lymphocyte antigen 6 complex locus protein G6d isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087117
      UniProtKB/TrEMBL
      A0A1L6ZA43

    2. NM_001371028.1 → NP_001357957.1  lymphocyte antigen 6 complex locus protein G6d isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087117
      UniProtKB/TrEMBL
      A0A1L6ZA36

    3. NM_033478.3 → NP_258439.1  lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor

      See identical proteins and their annotated locations for NP_258439.1

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS28678.1
      UniProtKB/Swiss-Prot
      Q9Z1Q3
      UniProtKB/TrEMBL
      A0A1L6ZA36
      Related
      ENSMUSP00000007259.4, ENSMUST00000007259.4

    RNA

    1. NR_163839.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117

    2. NR_163840.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117

    3. NR_163841.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117

    4. NR_163842.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Related
      ENSMUST00000172639.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35290318..35300215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003726.1: Suppressed sequence

      Description
      NM_001003726.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_176969.3: Suppressed sequence

      Description
      NM_176969.3: This RefSeq was permanently suppressed because insufficient support exists for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1Q3.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Q3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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