Arhgdia Rho GDP dissociation inhibitor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgdiaprovided by MGI
Official Full Name: Rho GDP dissociation inhibitor alphaprovided by MGI
Primary source: MGI:MGI:2178103
See related: Ensembl:ENSMUSG00000025132 AllianceGenome:MGI:2178103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gdi-1; RhoDGI; Rho-GDI; RhoGDI-1; rho GDI 1; 5330430M07Rik; Rho GDI alpha; rho-GDI alpha
Summary: Enables Rho GDP-dissociation inhibitor activity. Involved in regulation of synaptic vesicle cycle and semaphorin-plexin signaling pathway. Acts upstream of or within Rho protein signal transduction and regulation of protein localization. Located in immunological synapse and nucleus. Is active in Schaffer collateral - CA1 synapse. Is expressed in brain; early nephron; and heart. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 291.0), lung adult (RPKM 246.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.29 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120468925..120472450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120578099..120581624, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
Title: A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
The Rho guanine dissociation inhibitor alpha inhibits skeletal muscle Rac1 activity and insulin action.
Title: The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action.
RhoGDIalpha regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Title: RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
Title: The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
Rho GDP dissociation inhibitor alpha silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling
Title: Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes
Title: Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.
The siRNA-mediated suppression of expression of alphaGDI especially affected vesicle dynamics.
Title: Impaired αGDI Function in the X-Linked Intellectual Disability: The Impact on Astroglia Vesicle Dynamics.
Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1.
Title: Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
RhoGDalpha controls ENaC expression and activity via Rac1.
Title: Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption.
Results identify a critical role for 14-3-3tau in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIalpha, a negative regulator of Rho GTPases and a metastasis suppressor.
Title: 14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 1

Names: Rho GDIalpha; Rho GDP dissociation inhibitor (GDI) alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.